Umapathy Sundaram, MD, AGAF

Vice Dean, Research & Graduate Education; Chairman, Department of Clinical & Translational Science


Clinical Interests



Dr. Sundaram is a fellowship-trained, board-certified gastroenterologist specializing in the care of patients with inflammatory bowel disease and hepatobiliary diseases and in therapeutic biliary endoscopy.

In addition to his role as a clinician, Dr. Sundaram serves as vice dean of research and graduate medical education for the Marshall University Joan C. Edwards School of Medicine. He is an avid researcher and has demonstrated a commitment to basic, clinical and translational research dating back to his undergraduate training in Bioengineering at Johns Hopkins University. During this time, his research in the National Institutes on Aging led to multiple co-authored publications in blood brain barrier drug entry and distribution modeling. In 2006, Dr. Sundaram established the Digestive Disease Fellowship Training Program at WVU HSC, the only GI fellowship training program in the state. Dr. Sundaram’s research is currently funded by two National Institutes of Health (NIH) R01 grants to study regulation of nutrient and electrolyte malabsorption in inflammatory bowel disease. He has and continues to serve on numerous study sections both in NIDDK and at the Veterans Affairs Merit Review.

Education & Training

  • Medical School: The Medical College of Toledo (Toledo, Ohio)
  • Residency: University of Michigan Medical Center (Ann Arbor, Mich.)
  • Fellowship: Yale University School of Medicine (New Haven, Conn.)

Honors & Memberships

  • Fellow, American Gastroenterological Association
  • Member, American Gastroenterological Association
  • Member, Gastroenterology Research Group
  • Member, American College of Gastroenterology
  • Member, American College of Physicians
  • Member, American Physiological Society
  • Member, Federation of American Society of Experimental Biology
  • Member, Society for Clinical and Translational Science
  • Member, American Medical Informatics Association
  • Member, Association of Academic Health Centers
  • Member, West Virginia State Medical Association
  • Member, Southern Society of Clinical Investigation


  • Certified: American Board of Internal Medicine, subspecialty certification in Gastroenterology
  • Certified: National Board of Medical Examiners

Marshall Internal Medicine

A provider-based department of Cabell Huntington Hospital
Erma Ora Byrd Clinical Center
1249 15th Street
2nd & 3rd Floor
Huntington, WV 25701
Phone: 304.691.1000

Map & Directions

Islam MR, Arthur S, Haynes J, Butts MR, Nepal N, Sundaram U. 2022. The Role of Gut Microbiota and Metabolites in Obesity-Associated Chronic Gastrointestinal Disorders. Nutrients. 2022 3 16;14(3).
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Haynes J, Palaniappan B, Tsopmegha E, Sundaram U. 2022. Regulation of nutrient and electrolyte absorption in human organoid-derived intestinal epithelial cell monolayers. Transl Res. 2022 Oct;248:22-35
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Nepal N, Arthur S, Haynes J, Palaniappan B, Sundaram U. 2021. Mechanism of Na-K-ATPase Inhibition by PGE2 in Intestinal Epithelial Cells. Cells. 2021 10 21;10(4).
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Arthur S, Palaniappan B, Afroz S, Sundaram U. 2021. Unique Regulation of Coupled NaCl Absorption by Inducible Nitric Oxide in a Spontaneous SAMP1/YitFc Mouse Model of Chronic Intestinal Inflammation. Inflamm Bowel Dis. 2021 5 22.
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Thompson C, Rahman MM, Singh S, Arthur S, Sierra-Bakhshi C, Russell R, Denning K, Sundaram U, Salisbury T. 2021. The Adipose Tissue-Derived Secretome (ADS) in Obesity Uniquely Induces L-Type Amino Acid Transporter 1 (LAT1) and mTOR Signaling in Estrogen-Receptor-Positive Breast Cancer Cells. Int J Mol Sci. 2021 8 4;22(13).
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Khitan ZJ, Khawaja I, Mufson MA, Sanabria JR, Abraham NG, Peterson SJ, Sundaram U, Shapiro JI. 2020. Can charcoal improve outcomes in COVID-19 infections? Med Hypotheses. 2020 12 2;144:110176.
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Butts M, Singh S, Haynes J, Arthur S, Sundaram U. 2020. Moderate Alcohol Consumption Uniquely Regulates Sodium-Dependent Glucose Co-Transport in Rat Intestinal Epithelial Cells In Vitro and In Vivo. J. Nutr. 2020 Apr 1;150(4):747-755
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Arthur S, Manoharan P, Sundaram S, Rahman MM, Palaniappan B, Sundaram U. 2019. Unique Regulation of Enterocyte Brush Border Membrane Na-Glutamine and Na-Alanine Co-Transport by Peroxynitrite during Chronic Intestinal Inflammation. Int J Mol Sci. 2019 3 29;20(6).
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Butts M, Singh Paulraj R, Haynes J, Arthur S, Singh S, Sundaram U. 2019. Moderate Alcohol Consumption Inhibits Sodium-Dependent Glutamine Co-Transport in Rat Intestinal Epithelial Cells in Vitro and Ex Vivo. Nutrients. 2019 Oct 18;11(10):2516
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Palaniappan B, Sundaram U. 2018. Direct and specific inhibition of constitutive nitric oxide synthase uniquely regulates brush border membrane Na-absorptive pathways in intestinal epithelial cells. Nitric Oxide. 2018 4 28;79:8-13.
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Manoharan P, Sundaram S, Singh S, Sundaram U. 2018. Inducible Nitric Oxide Regulates Brush Border Membrane Na-Glucose Co-transport, but Not Na:H Exchange via p38 MAP Kinase in Intestinal Epithelial Cells. Cells. 2018 8 22;7(8).
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Arthur S, Singh S, Sundaram U. 2018. Cyclooxygenase pathway mediates the inhibition of Na-glutamine co-transporter B0AT1 in rabbit villus cells during chronic intestinal inflammation. PLoS ONE. 2018 9 8;13(9):e0203552.
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Singh S, Arthur S, Sundaram U. 2017. Unique regulation of Na-glutamine cotransporter SN2/SNAT5 in rabbit intestinal crypt cells during chronic enteritis. J. Cell. Mol. Med. 2017 12 23;22(3):1443-1451.
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Singh S, Arthur S, Sundaram U.. 2017.
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Singh S, Arthur S, Talukder J, Palaniappan B, Coon S, Sundaram U. 2016. Mast cell regulation of Na-glutamine co-transporters B0AT1 in villus and SN2 in crypt cells during chronic intestinal inflammation. BMC Gastroenterol. 2016 2 24;15:47.
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Saha P, Manoharan P, Arthur S, Sundaram S, Kekuda R, Sundaram U. 2015. Molecular mechanism of regulation of villus cell Na-K-ATPase in the chronically inflamed mammalian small intestine. Biochim. Biophys. Acta. 2015 Feb;1848(2):702-11.
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Manoharan P, Gayam S, Arthur S, Palaniappan B, Singh S, Dick GM, Sundaram U. 2015. Chronic and selective inhibition of basolateral membrane Na-K-ATPase uniquely regulates brush border membrane Na absorption in intestinal epithelial cells. Am. J. Physiol., Cell Physiol. 2015 7 24;308(8):C650-6.
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Arthur S, Sundaram U. 2014. Protein kinase C-mediated phosphorylation of RKIP regulates inhibition of Na-alanine cotransport by leukotriene D4 in intestinal epithelial cells. Am. J. Physiol., Cell Physiol. 2014 Dec 1;307(11):C1010-6.
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Arthur S, Sundaram U. 2014. Inducible nitric oxide regulates intestinal glutamine assimilation during chronic intestinal inflammation. Nitric Oxide. 2014 Dec 15;44C:98-104.
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Arthur S, Coon S, Kekuda R, Sundaram U. 2014. Regulation of sodium glucose co-transporter SGLT1 through altered glycosylation in the intestinal epithelial cells. Biochim. Biophys. Acta. 2014 May;1838(5):1208-14.
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Kekuda R, Manoharan P, Baseler W, Sundaram U. 2013. Monocarboxylate 4 mediated butyrate transport in a rat intestinal epithelial cell line. Dig. Dis. Sci. 2013 Mar;58(3):660-7.
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Manoharan P, Coon S, Baseler W, Sundaram S, Kekuda R, Sundaram U. 2013. Prostaglandins, not the leukotrienes, regulate Cl(-)/HCO(3)(-) exchange (DRA, SLC26A3) in villus cells in the chronically inflamed rabbit ileum. Biochim. Biophys. Acta. 2013 Feb;1828(2):179-86.
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Arthur S, Saha P, Sundaram S, Kekuda R, Sundaram U. 2012. Regulation of sodium-glutamine cotransport in villus and crypt cells by glucocorticoids during chronic enteritis. Inflamm. Bowel Dis. 2012 Nov;18(11):2149-57.
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Saha P, Arthur S, Kekuda R, Sundaram U. 2012. Na-glutamine co-transporters B(0)AT1 in villus and SN2 in crypts are differentially altered in chronically inflamed rabbit intestine. Biochim. Biophys. Acta. 2012 Mar;1818(3):434-42.
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Talukder JR, Kekuda R, Saha P, Arthur S, Sundaram U. 2008. Identification and characterization of rabbit small intestinal villus cell brush border membrane Na-glutamine cotransporter. Am. J. Physiol. Gastrointest. Liver Physiol. 2008 Jul;295(1):G7-G15.
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