Krista L. Denning, MD

Professor
Chair, Department of Pathology; Medical Director, Marshall Toxicology

Departments

Clinical Interests

Privileges

Dr. Denning has a special interest in anatomic and clinical pathology as well as cytopathology.

Education & Training

  • Medical School: Marshall University Joan C. Edwards School of Medicine (Huntington, W.Va.)
  • Residency: Allegheny General Hospital (Pittsburgh, Pa.)
  • Fellowship: Allegheny General Hospital (Pittsburgh, Pa.)

Certification

  • Certified: American Board of Pathology in Anatomic Pathology, subspecialty certification in Cytopathology

Valluri A, Wellman J, McCallister CL, Brown KC, Lawrence L, Russell R, Jensen J, Denvir J, Valentovic MA, Denning KL, Salisbury TB. 2023. mTOR Regulation of N-Myc Downstream Regulated 1 (NDRG1) Phosphorylation in Clear Cell Renal Cell Carcinoma. Int J Mol Sci. 2023 5 27;24(11).
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Chen X, Denning KL, Mazur A, Lawrence LM, Wang X, Lu Y. 2023. Under peroxisome proliferation acyl-CoA oxidase coordinates with catalase to enhance ethanol metabolism. Free Radic Biol Med. Chen X, Denning KL, Mazur A, Lawrence LM, Wang X, Lu Y. Under peroxisome proliferation acyl-CoA oxidase coordinates with catalase to enhance ethanol metabolism. Free Radic Biol Med. 2023 Aug 9;208:221-228.
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Brown K, Modi K, Light R, Cox A, Long T, Gadepalli RS, Rimoldi J, Miles S, Rankin G, Valentovic M, Denning K, Tirona M, Finch P, Hess J, Dasgupta P. 2023. Anti-cancer Activity of Region B capsaicin analogs 2023 March 31, 66 (7): 4294-4323.

Xu Y, Denning KL, Lu Y. 2022. PPARa agonist WY-14,643 induces the PLA2/COX-2/ACOX1 pathway to enhance peroxisomal lipid metabolism and ameliorate alcoholic fatty liver in mice. Biochem Biophys Res Commun. 2022 5 8;613:47-52.
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Lamba C, Denning K, Ouellette E, Kurtz S, Bullock M. 2021. An Interesting Case of Osteolysis With Accompanying Metallosis in a Primary Total Knee Arthroplasty Arthroplasty Today 2021 Oct 1; 11:81-7
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Thompson C, Rahman MM, Singh S, Arthur S, Sierra-Bakhshi C, Russell R, Denning K, Sundaram U, Salisbury T. 2021. The Adipose Tissue-Derived Secretome (ADS) in Obesity Uniquely Induces L-Type Amino Acid Transporter 1 (LAT1) and mTOR Signaling in Estrogen-Receptor-Positive Breast Cancer Cells. Int J Mol Sci. 2021 8 4;22(13).
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Chen X, Xu Y, Denning KL, Grigore A, Lu Y. 2021. PPARa agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase. Free Radic Biol Med. 2021 4 23;169:283-293.
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Yasin H, Yadala V, Khan NAJ, Graffeo V, Denning K, Lebowicz Y. 2021. Immunotherapy-Induced Sarcoid-Like Reaction: A Shrewd Imitator. J Investig Med High Impact Case Rep. 2021 10 16;9:23247096211009400.
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Xu Y, Denning KL, Lu Y. 2021. PPARa agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1. Biochem Pharmacol. 2021 7 15;192:114678.
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Chen X, Acquaah-Mensah GK, Denning KL, Peterson JM, Wang K, Denvir J, Hong F, Cederbaum AI, Lu Y. 2020. High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARa: a new model for steatohepatitis-associated fibrosis. Am J Physiol Gastrointest Liver Physiol. 2020 9 3;319(5):G626-G635.
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Howard CM, Zgheib NB, Bush S, DeEulis T, Cortese A, Mollo A, Lirette ST, Denning K, Valluri J, Claudio PP. 2020. Clinical relevance of cancer stem cell chemotherapeutic assay for recurrent ovarian cancer. Transl Oncol. 2020 8 31;13(12):100860.
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logan lawrence, rebecca russell, Claire Denning, Nadim bou Zgheib, Travis Salisbury, Seth Lirette, Jagan Valluri, Pier Paulo Claudio, Krista Denning. 2020. Expression of poly-ADP-ribose polymerase (PARP) in endometrial adenocarcinoma: prognostic potential 2020 Jun;216(6):152965.
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Ranjan T, Howard CM, Yu A, Xu L, Aziz K, Jho D, Leonardo J, Hameed MA, Karlovits SM, Wegner RE, Fuhrer R, Lirette ST, Denning KL, Valluri J, Claudio PP. 2020. Cancer Stem Cell Chemotherapeutics Assay for Prospective Treatment of Recurrent Glioblastoma and Progressive Anaplastic Glioma: A Single-Institution Case Series. Transl Oncol. 2020 3 21;13(4):100755.
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Lawrence LM, Russell R, Denning CE, Zgheib NB, Salisbury T, Lirette ST, Valluri J, Claudio PP, Denning KL. 2020. Expression of poly-ADP-ribose polymerase (PARP) in endometrial adenocarcinoma: Prognostic potential. Pathol. Res. Pract. 2020 5 4;216(6):152965.
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Lawrence LM, Cottrill A, Valluri A, Marenzi G, Denning KL, Valluri J, Claudio PP, Day JB. 2019. Minimally Manipulative Method for the Expansion of Human Bone Marrow Mesenchymal Stem Cells to Treat Osseous Defects. Int J Mol Sci. 2019 2 3;20(3).
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Friedman JR, Richbart SD, Merritt JC, Brown KC, Denning KL, Tirona MT, Valentovic MA, Miles SL, Dasgupta P. 2019. Capsaicinoids: Multiple effects on angiogenesis, invasion and metastasis in human cancers. Biomed. Pharmacother. 2019 8 13;118:109317.
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Merry-Sperry AD, Chaffin DG, Denning KL, Shamma B, Massey C, Werthammer J. 2018. Placental Chorioangioma with Nonimmune Hydrops Fetalis. South. Med. J. 2018 8 4;111(8):457-459.
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Dotson J, Nijim A, Denning KL, Shweihat Y, Lebowicz Y. 2018. A Rare Case of Metastases from a High-grade Astrocytoma to the Pleura, Bones, and Liver within Six Months of Diagnosis. Cureus. 2018 11 10;10(8):e3234.
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Katz H, Saad RE, Denning K, Pacioles TO. 2017. A Rare Case of Esophageal Adenocarcinoma with Urinary Bladder Metastasis. Case Rep Gastrointest Med. 2017 6 24;2017:9343896.
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Friedman JR, Perry HE, Brown KC, Gao Y, Lin J, Stevenson CD, Hurley JD, Nolan NA, Akers AT, Chen YC, Denning KL, Brown LG, Dasgupta P.. 2017. Capsaicin synergizes with camptothecin to induce increased apoptosis in human small cell lung cancers via the calpain pathway. Biochem. Pharmacol. Biochem Pharmacol. 2017 Apr 1;129:54-66.
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Howard CM, Valluri J, Alberico A, Julien T, Mazagri R, Marsh R, Alastair H, Cortese A, Griswold M, Wang W, Denning K, Brown L, Claudio PP. 2017. Analysis of Chemopredictive Assay for Targeting Cancer Stem Cells in Glioblastoma Patients. Transl Oncol. Transl Oncol. 2017 Apr;10(2):241-254.
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Oakley GJ 3rd, Denning KL, Graffeo V, Griswold DC, Davis AR, Brown LG.. 2016. Same difference: A pilot study of cyclin D1, bcl-2, AMACR, and ALDH-1 identifies significant differences in expression between primary colon adenocarcinoma and its metastases. Pathol. Res. Pract. Pathol Res Pract. 2016 Nov;212(11):995-1003.
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Khelfa Y, Mansour M, Abdel-Aziz Y, Raufi A, Denning K, Lebowicz Y. 2016. Relapsed Acinic Cell Carcinoma of the Parotid Gland With Diffuse Distant Metastasis: Case Report With Literature Review. J Investig Med High Impact Case Rep. .
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Shenouda M, Brown LG, Denning KL, Pacioles T. 2016. A Case of Oncocytic Adrenocortical Neoplasm of Borderline (Uncertain) Malignant Potential. Cureus. 2016 Jun;8(6):e638.
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Morra F, Luise C, Merolla F, Poser I, Visconti R, Ilardi G, Paladino S, Inuzuka H, Guggino G, Monaco R, Colecchia D, Monaco G, Cerrato A, Chiariello M, Denning K, Claudio PP, Staibano S, Celetti A. 2015. FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC. Oncotarget. 2015 May 20;6(14):12697-709.
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Mathis SE, Alberico A, Nande R, Neto W, Lawrence L, McCallister DR, Denvir J, Kimmey GA, Mogul M, Oakley G, Denning KL, Dougherty T, Valluri JV, Claudio PP. 2014. Chemo-predictive assay for targeting cancer stem-like cells in patients affected by brain tumors. PLoS ONE. 2014 Aug;9(8):e105710.
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Maghrabi A, Yaqub A, Denning KL, Benhamed N, Faiz S, Saleem T. 2013. Challenges in the Diagnostic Work-Up and Management of Patients with SCS and Bilateral Adrenal Masses. Endocr Pract. 2013 May-Jun;19(3):515-21
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Denning KL, Al-Subu A, Elitsur Y. 2013. Immunoreactivity of p53 and Ki-67 for dysplastic changes in children with eosinophilic esophagitis. Pediatr. Dev. Pathol. 2013 May;16(5):331-6.
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Kilgore J, Bowers R, Denning K, Bou Zgheib N. . Positive BCOR ITD high grade endometrial stromal sarcoma discovered after miscarriage