Krista L. Denning, MD

Professor
Interim Chair, Department of Pathology

Departments

Clinical Interests

Biography

Dr. Denning has a special interest in anatomic and clinical pathology as well as cytopathology.

Education & Training

  • Medical School: Marshall University Joan C. Edwards School of Medicine (Huntington, W.Va.)
  • Residency: Allegheny General Hospital (Pittsburgh, Pa.)
  • Fellowship: Allegheny General Hospital (Pittsburgh, Pa.)

Certification

  • Certified: American Board of Pathology in Anatomic Pathology, subspecialty certification in Cytopathology
Krista L. Denning, MD, is not currently accepting new patients at Marshall Health.

Richbart S, Friedman J, Akers A, Nolan N, Brown K, Miles S, Bow E, Rimoldi J, Chen Y, Denning K, Dasgupta P.. 2021. Anti-tumor and Anti-Angiogenic activity of the Choline Acetyltransferase Inhibitor BW813U, in Human Lung Adenocarcinoma 2021 May; 35(S1).

Lamba C, Denning K, Ouellette E, Kurtz S, Bullock M. 2021. An Interesting Case of Osteolysis With Accompanying Metallosis in a Primary Total Knee Arthroplasty Arthroplasty Today 2021 Oct 1; 11:81-7
View on PubMed

Pauley M, Mays C, Bailes JR, Schwartzman ML, Castle M, McCoy M, Patick C, Preston D, Nudelman MJR, Denning KL, Bellner L, Werthammer J. 2021. Carbohydrate-Restricted Diet: A Successful Strategy for Short-Term Management in Youth with Severe Obesity-An Observational Study. Metab Syndr Relat Disord. 2021 2 11.
View on PubMed

Chen X, Acquaah-Mensah GK, Denning KL, Peterson JM, Wang K, Denvir J, Hong F, Cederbaum AI, Lu Y. 2020. High fat diet induces fibrosis in mice lacking CYP2A5 and PPARa: A new model for steatohepatitis-associated fibrosis. Am. J. Physiol. Gastrointest. Liver Physiol. 2020 9 3.
View on PubMed

Howard CM, Zgheib NB, Bush S, DeEulis T, Cortese A, Mollo A, Lirette ST, Denning K, Valluri J, Claudio PP. 2020. Clinical relevance of cancer stem cell chemotherapeutic assay for recurrent ovarian cancer. Transl Oncol. 2020 8 31;13(12):100860.
View on PubMed

logan lawrence, rebecca russell, Claire Denning, Nadim bou Zgheib, Travis Salisbury, Seth Lirette, Jagan Valluri, Pier Paulo Claudio, Krista Denning. 2020. Expression of poly-ADP-ribose polymerase (PARP) in endometrial adenocarcinoma: prognostic potential 2020 Jun;216(6):152965.
View on PubMed

Ranjan T, Howard CM, Yu A, Xu L, Aziz K, Jho D, Leonardo J, Hameed MA, Karlovits SM, Wegner RE, Fuhrer R, Lirette ST, Denning KL, Valluri J, Claudio PP. 2020. Cancer Stem Cell Chemotherapeutics Assay for Prospective Treatment of Recurrent Glioblastoma and Progressive Anaplastic Glioma: A Single-Institution Case Series. Transl Oncol. 2020 3 21;13(4):100755.
View on PubMed

Lawrence LM, Russell R, Denning CE, Zgheib NB, Salisbury T, Lirette ST, Valluri J, Claudio PP, Denning KL. 2020. Expression of poly-ADP-ribose polymerase (PARP) in endometrial adenocarcinoma: Prognostic potential. Pathol. Res. Pract. 2020 5 4;216(6):152965.
View on PubMed

Lawrence LM, Cottrill A, Valluri A, Marenzi G, Denning KL, Valluri J, Claudio PP, Day JB. 2019. Minimally Manipulative Method for the Expansion of Human Bone Marrow Mesenchymal Stem Cells to Treat Osseous Defects. Int J Mol Sci. 2019 2 3;20(3).
View on PubMed

Friedman JR, Richbart SD, Merritt JC, Brown KC, Denning KL, Tirona MT, Valentovic MA, Miles SL, Dasgupta P. 2019. Capsaicinoids: Multiple effects on angiogenesis, invasion and metastasis in human cancers. Biomed. Pharmacother. 2019 8 13;118:109317.
View on PubMed

Merry-Sperry AD, Chaffin DG, Denning KL, Shamma B, Massey C, Werthammer J. 2018. Placental Chorioangioma with Nonimmune Hydrops Fetalis. South. Med. J. 2018 8 4;111(8):457-459.
View on PubMed

Dotson J, Nijim A, Denning KL, Shweihat Y, Lebowicz Y. 2018. A Rare Case of Metastases from a High-grade Astrocytoma to the Pleura, Bones, and Liver within Six Months of Diagnosis. Cureus. 2018 11 10;10(8):e3234.
View on PubMed

Katz H, Saad RE, Denning K, Pacioles TO. 2017. A Rare Case of Esophageal Adenocarcinoma with Urinary Bladder Metastasis. Case Rep Gastrointest Med. 2017 6 24;2017:9343896.
View on PubMed

Friedman JR, Perry HE, Brown KC, Gao Y, Lin J, Stevenson CD, Hurley JD, Nolan NA, Akers AT, Chen YC, Denning KL, Brown LG, Dasgupta P.. 2017. Capsaicin synergizes with camptothecin to induce increased apoptosis in human small cell lung cancers via the calpain pathway. Biochem. Pharmacol. Biochem Pharmacol. 2017 Apr 1;129:54-66.
View on PubMed

Howard CM, Valluri J, Alberico A, Julien T, Mazagri R, Marsh R, Alastair H, Cortese A, Griswold M, Wang W, Denning K, Brown L, Claudio PP. 2017. Analysis of Chemopredictive Assay for Targeting Cancer Stem Cells in Glioblastoma Patients. Transl Oncol. Transl Oncol. 2017 Apr;10(2):241-254.
View on PubMed

Shenouda M, Brown LG, Denning KL, Pacioles T.. 2016. A Case of Oncocytic Adrenocortical neoplasm of Borderline (Uncertain) Malignant Potential. Cureus. 2016 Jun 13;8(6):e638. doi: 10.7759/cureus.638.
View on PubMed

Oakley GJ 3rd, Denning KL, Graffeo V, Griswold DC, Davis AR, Brown LG.. 2016. Same difference: A pilot study of cyclin D1, bcl-2, AMACR, and ALDH-1 identifies significant differences in expression between primary colon adenocarcinoma and its metastases. Pathol. Res. Pract. Pathol Res Pract. 2016 Nov;212(11):995-1003.
View on PubMed

Khelfa Y, Mansour M, Abdel-Aziz Y, Raufi A, Denning K, Lebowicz Y. 2016. Relapsed Acinic Cell Carcinoma of the Parotid Gland With Diffuse Distant Metastasis: Case Report With Literature Review. J Investig Med High Impact Case Rep. .
View on PubMed

Shenouda M, Brown LG, Denning KL, Pacioles T. 2016. A Case of Oncocytic Adrenocortical Neoplasm of Borderline (Uncertain) Malignant Potential. Cureus. 2016 Jun;8(6):e638.
View on PubMed

Gerald Oakley III, MD, Krista Denning, MD, Vincent Graffeo, MD, Doreen Griswold, MD, Adam Davis, BS, Linda Brown, MD. 2016. Same difference: A pilot study of cyclin D1, bcl-2, AMACR, and ALDH-1 identifies significant differences in expression between primary colon adenocarcinoma and its metastases. Pathol. Res. Pract. Pathol Res Pract. 2016 Nov;212(11):995-1003. doi: 10.1016/j.prp.2016.08.004. Epub 2016 Aug 22.
View on PubMed

Morra F, Luise C, Merolla F, Poser I, Visconti R, Ilardi G, Paladino S, Inuzuka H, Guggino G, Monaco R, Colecchia D, Monaco G, Cerrato A, Chiariello M, Denning K, Claudio PP, Staibano S, Celetti A. 2015. FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC. Oncotarget. 2015 May 20;6(14):12697-709.
View on PubMed

Mathis SE, Alberico A, Nande R, Neto W, Lawrence L, McCallister DR, Denvir J, Kimmey GA, Mogul M, Oakley G, Denning KL, Dougherty T, Valluri JV, Claudio PP. 2014. Chemo-predictive assay for targeting cancer stem-like cells in patients affected by brain tumors. PLoS ONE. 2014 Aug;9(8):e105710.
View on PubMed

Maghrabi A, Yaqub A, Denning KL, Benhamed N, Faiz S, Saleem T. 2013. Challenges in the Diagnostic Work-Up and Management of Patients with SCS and Bilateral Adrenal Masses. Endocr Pract. 2013 May-Jun;19(3):515-21
View on PubMed

Denning KL, Al-Subu A, Elitsur Y. 2013. Immunoreactivity of p53 and Ki-67 for dysplastic changes in children with eosinophilic esophagitis. Pediatr. Dev. Pathol. 2013 May;16(5):331-6.
View on PubMed

Kilgore J, Bowers R, Denning K, Bou Zgheib N. . Positive BCOR ITD high grade endometrial stromal sarcoma discovered after miscarriage