Komal Sodhi, MD

Associate Professor

Departments

Biography

Dr. Sodhi's principle research focus is to investigate contributions of chronic oxidative stress and metabolic imbalance as it pertains to development of obesity and diabetes with associated long-term complications. Past research has focused on physiological and molecular aspects at (dys) regulation of the cellular antioxidant defense system i.e. the heme-heme oxygenase system in association with chronic redox imbalance. She has also studied the impact of adipocyte dysfunction on vascular endothelial integrity through the prism of heme oxygenase.

Dr. Sodhi's research also entails examining HO-dependent regulation of eicosanoids and their physiological effects, particularly in the vasculature and perivascular adipocytes. Her diverse research projects have encompassed cell culture, animal models, molecular and cell biology and oganotypic cultures.

Education & Training

  • Medical School: Mahatma Gandhi Memorial Medical College (Indore, India)
  • Residency: Jaipur Golden Hospital (New Delhi, India)

Honors & Memberships

  • Member, American Heart Association
Komal Sodhi, MD, is not currently accepting new patients at Marshall Health.

Liu J, Tian J, Sodhi K, Shapiro JI. 2021. The Na/K-ATPase Signaling and SGLT2 Inhibitor-Mediated Cardiorenal Protection: A Crossed Road? J Membr Biol. 2021 7 24.
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Sergi CM, Udoh UA, Sanabria JD, Rajan PK, Banerjee M, Schade M, Sanabria JA, Smith G, Udoh G, Sodhi K, Pierre S, Shapiro JI, Sanabria JR. 2021. Non-Alcoholic Fatty Liver Disease Progression to Non-Alcoholic Steatohepatitis-Related Primary Liver Cancer 2021 4 28.
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Zehra M, Curry JC, Pillai SS, Lakhani HV, Edwards CE, Sodhi K. 2020. Elucidating Potential Profibrotic Mechanisms of Emerging Biomarkers for Early Prognosis of Hepatic Fibrosis. Int J Mol Sci. 2020 7 9;21(13).
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Lakhani HV, Pillai SS, Zehra M, Sharma I, Sodhi K. 2020. Systematic Review of Clinical Insights into Novel Coronavirus (CoVID-19) Pandemic: Persisting Challenges in U.S. Rural Population. Int J Environ Res Public Health. 2020 6 26;17(12).
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Sodhi K, Denvir J, Liu J, Sanabria JR, Chen Y, Silverstein R, Xie Z, Abraham NG, Shapiro JI. 2020. Oxidant-Induced Alterations in the Adipocyte Transcriptome: Role of the Na,K-ATPase Oxidant Amplification Loop 2020 Aug 18;21(16):5923.

Tun S, Spainhower CJ, Cottrill CL, Lakhani HV, Pillai SS, Dilip A, Chaudhry H, Shapiro JI, Sodhi K. 2020. Therapeutic Efficacy of Antioxidants in Ameliorating Obesity Phenotype and Associated Comorbidities. Front Pharmacol. 2020 9 10;11:1234.
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Rajan PK, Udoh UA, Sanabria JD, Banerjee M, Smith G, Schade MS, Sanabria J, Sodhi K, Pierre S, Xie Z, Shapiro JI, Sanabria J. 2020. The Role of Histone Acetylation-/Methylation-Mediated Apoptotic Gene Regulation in Hepatocellular Carcinoma. Int J Mol Sci. 2020 12 2;21(23).
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Xie ZJ, Novograd J, Itzkowitz Y, Sher A, Buchen YD, Sodhi K, Abraham NG, Shapiro JI. 2020. The Pivotal Role of Adipocyte-Na K peptide in Reversing Systemic Inflammation in Obesity and COVID-19 in the Development of Heart Failure. Antioxidants (Basel). 2020 11 19;9(11).
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Maxwell KD, Chuang J, Chaudhry M, Nie Y, Bai F, Sodhi K, Liu J, Shapiro JI. 2020. The potential role of Na-K-ATPase and its signaling in the development of anemia in chronic kidney disease. Am J Physiol Renal Physiol. 2020 12 28;320(2):F234-F242.
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Liu J, Nie Y, Chaudhry M, Bai F, Chuang J, Sodhi K, Shapiro JI. 2020. The Redox-Sensitive Na/K-ATPase Signaling in Uremic Cardiomyopathy. Int J Mol Sci. 2020 2 20;21(4).
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Nie Y, Bai F, Chaudhry MA, Pratt R, Shapiro JI, Liu J. 2020. The Na/K-ATPase a1 and c-Src form signaling complex under native condition: A crosslinking approach. Sci Rep. 2020 4 9;10(1):6006.
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Sodhi K, Wang X, Chaudhry MA, Lakhani HV, Zehra M, Pratt R, Nawab A, Cottrill CL, Snoad B, Bai F, Denvir J, Liu J, Sanabria JR, Xie Z, Abraham NG, Shapiro JI. 2020. Central Role for Adipocyte Na,K-ATPase Oxidant Amplification Loop in the Pathogenesis of Experimental Uremic Cardiomyopathy. J. Am. Soc. Nephrol. 2020 6 27.
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Pillai, SS, Lakhani, HV, Zehra, M, Wang, J, Dilip, A., Puri, N., O'Hanlon, KM, Sodhi, K. 2020. “Predicting non-alcoholic steatohepatitis through a panel of plasma biomarkers and microRNAs in Female West Virginia population” 2020 Sep; 21(18): 6698. Published online 2020 Sep 13. doi: 10.3390/ijms21186698

Pratt RD, Brickman C, Nawab A, Cottrill C, Snoad B, Lakhani HV, Jelcick A, Henderson B, Bhardwaj NN, Sanabria JR, Liu J, Xie Z, Abraham NG, Shapiro JI, Sodhi K. 2019. The Adipocyte Na/K-ATPase Oxidant Amplification Loop is the Central Regulator of Western Diet-Induced Obesity and Associated Comorbidities. Sci Rep. 2019 5 30;9(1):7927.
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Lakhani HV, Zehra M, Pillai SS, Puri N, Shapiro JI, Abraham NG, Sodhi K. 2019. Beneficial Role of HO-1-SIRT1 Axis in Attenuating Angiotensin II-Induced Adipocyte Dysfunction. Int J Mol Sci. 2019 7 3;20(13).
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Yan Y, Wang J, Chaudhry MA, Nie Y, Sun S, Carmon J, Shah PT, Bai F, Pratt R, Brickman C, Sodhi K, Kim JH, Pierre S, Malhotra D, Rankin GO, Xie ZJ, Shapiro JI, Liu J. 2019. Metabolic Syndrome and Salt-Sensitive Hypertension in Polygenic Obese TALLYHO/JngJ Mice: Role of Na/K-ATPase Signaling. Int J Mol Sci. 2019 7 19;20(14).
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Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding PJ, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, Malarkannan S, Sodhi K, Shapiro JI, Xie Z, Sahoo D, Silverstein RL. 2019. Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses. Circ. Res. 2019 10 19.
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Lakhani HV, Khanal T, Gabi A, Yousef G, Alam MB, Sharma D, Aljoudi H, Puri N, Thompson E, Shapiro JI, Sodhi K. 2019. Developing a panel of biomarkers and miRNA in patients with myocardial infarction for early intervention strategies of heart failure in West Virginian population. PLoS ONE. 2019 3 21;13(10):e0205329.
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Yan Y, Wang J, Chaudhry MA, Nie Y, Sun S, Carmon J, Shah PT, Bai F, Pratt R, Brickman C, Sodhi K, Kim JH, Pierre S, Malhotra D, Rankin GO, Xie ZJ, Shapiro JI, Liu J.. 2019. Metabolic Syndrome and Salt-Sensitive Hypertension in Polygenic Obese TALLYHO/JngJ Mice: Role of N/K-ATPase Signaling. 2019 Jul 16;20(14).
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Bartlett DE, Miller RB, Thiesfeldt S, Lakhani HV, Khanal T, D Pratt R, Cottrill CL, Klug RL, Adkins NS, Bown PC, Nease DB, Shapiro JI, Sodhi K. 2018. Uremic Toxins Activates Na/K-ATPase Oxidant Amplification Loop Causing Phenotypic Changes in Adipocytes in In Vitro Models. Int J Mol Sci. 2018 12 26;19(9).
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Bartlett DE, Miller RB, Thiesfeldt S, Lakhani HV, Shapiro JI, Sodhi K. 2018. The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Aging: Implications in Obesity and Cardiovascular Disease. Int J Mol Sci. 2018 7 26;19(7).
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Ashktorab H, Soleimani A, Nichols A, Sodhi K, Laiyemo AO, Nunlee-Bland G, Nouraie SM, Brim H. 2018. Adiponectin, Leptin, IGF-1, and Tumor Necrosis Factor Alpha As Potential Serum Biomarkers for Non-Invasive Diagnosis of Colorectal Adenoma in African Americans. Front Endocrinol (Lausanne). 2018 3 30;9:77.
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Lakhani HV, Sharma D, Dodrill MW, Nawab A, Sharma N, Cottrill CL, Shapiro JI, Sodhi K. 2018. Phenotypic Alteration of Hepatocytes in Non-Alcoholic Fatty Liver Disease. Int J Med Sci. 2018 12 28;15(14):1591-1599.
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Sodhi K, Nichols A, Mallick A, Klug RL, Liu J, Wang X, Srikanthan K, Goguet-Rubio P, Nawab A, Pratt R, Lilly MN, Sanabria JR, Xie Z, Abraham NG, Shapiro JI. 2018. The Na/K-ATPase Oxidant Amplification Loop Regulates Aging. Sci Rep. 2018 6 28;8(1):9721.
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Goguet-Rubio, P, Klug, R.L., Lakhani, V.H, Nichols, A, Dana L. Sharma, D.L., Srikanthan, K., Puri, N. O’Hanlon, K.M.,Shapiro JI. 2017. Existence of a Strong Correlation of Biomarkers and miRNA in Females with Metabolic Syndrome and Obesity in a Population of West Virginia. Int J Med Sci. 2017 Mar
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Puri N, Arefiev Y, Chao R, Sacerdoti D, Chaudry H, Nichols A, Srikanthan K, Nawab A, Sharma D, Lakhani VH, Klug R, Sodhi K, Peterson SJ. 2017. Heme Oxygenase Induction Suppresses Hepatic Hepcidin and Rescues Ferroportin and Ferritin Expression in Obese Mice. J Nutr Metab. 2017 10 25;2017:4964571.
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Sharma DL, Lakhani HV, Klug RL, Snoad B, El-Hamdani R, Shapiro JI, Sodhi K. 2017. Investigating Molecular Connections of Non-alcoholic Fatty Liver Disease with Associated Pathological Conditions in West Virginia for Biomarker Analysis. J Clin Cell Immunol. 2017 11 28;8(5).
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Srikanthan K, Klug R, Tirona M, Thompson E, Visweshwar H, Puri N, Shapiro JI, Sodhi K. 2017. Creating a Biomarker Panel for Early Detection of Chemotherapy Related Cardiac Dysfunction in Breast Cancer Patients.

Srikanthan K, Klug R, Tirona M, Thompson E, Visweshwar H, Puri N, Shapiro J, Sodhi K. 2017. Creating a Biomarker Panel for Early Detection of Chemotherapy Related Cardiac Dysfunction in Breast Cancer Patients. J Clin Exp Cardiolog. 2017 6 24;8(3).
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Nawab A, Nichols A, Klug R, Shapiro JI, Sodhi K. 2017. Spin Trapping: A Review for the Study of Obesity Related Oxidative Stress and Na(+)/K(+)-ATPase. J Clin Cell Immunol. 2017 8 18;8(3).
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KhitanZ , Shapiro A, Shah PT, Sanabria JR, Santhanam P, Sodhi, Abraham NG, Shapiro JI. 2017. Predicting Adverse Outcomes in Chronic Kidney Disease Using Machine Learning Methods: Data from the Modification of Diet in Renal Disease Marshall Journal of Medicine: Vol. 3: Iss. 4, Article 10.

Sodhi K Srikanthan K Goguet-Rubio P Nichols A Mallick A Nawab A Martin R Shah PT Chaudhry M Sigdel S El-Hamdani M Liu J Xie Z Abraham NG Shapiro JI. 2017. pNaKtide Attenuates Steatohepatitis and Atherosclerosis by Blocking Na/K-ATPase/ROS Amplification in C57Bl6 and ApoE Knockout Mice Fed a Western Diet SCI REP-UK 2017 Mar 15;7(1):193
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Srikanthan, K Feyh A Visweshwar H Shapiro JI Sodhi K. 2016. Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population Int J Med Sci 2016; 13(1):25-38. doi:10.7150/ijms.13800

Sodhi K, Bracero L, Feyh A, Nichols A, Srikanthan K, Latif T, Preston D, Shapiro JI, Elitsur Y. 2016. Role of Serum Biomarkers in Early Detection of Non-Alcoholic Steatohepatitis and Fibrosis in West Virginian Children. J Clin Cell Immunol. 2016 Feb;7(1).
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Waldman M, Bellner L, Vanella L, Schragenheim J, Sodhi K, Singh SP, Lin D, Lakhkar AD, Li J, Hochhauser E, Arad M, Darzynkiewicz Z, Kappas A, Abraham NG. 2016. Epoxyeicosatrienoic Acids Regulate Adipocyte Differentiation of Mouse 3T3 Cells, Via PGC-1a Activation, Which Is Required for HO-1 Expression and Increased Mitochondrial Function. Stem Cells Dev. 2016 May 25.
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Feyh A, Bracero L, Lakhani HV, Santhanam P, Shapiro JI, Khitan Z, Sodhi K. 2016. Role of Dietary Components in Modulating Hypertension. J Clin Exp Cardiolog. 2016 Apr;7(4).
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Shaver A, Nichols A, Thompson E, Mallick A, Payne K, Jones C, Manne ND, Sundaram S, Shapiro JI, Sodhi K. 2016. Role of Serum Biomarkers in Early Detection of Diabetic Cardiomyopathy in the West Virginian Population. Int J Med Sci. 2016 Feb;13(3):161-8.
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Peterson SJ, Vanella L, Gotlinger K, Jiang H, Singh SP, Sodhi K, Maher E, O'Hanlon K, Shapiro JI, Abraham NG. 2016. Oxidized HDL is a potent inducer of adipogenesis and causes activation of the Ang-II and 20-HETE systems in human obese females. Prostaglandins Other Lipid Mediat. 2016 May 11;123:68-77.
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Srikanthan K, Shapiro JI, Sodhi K. 2016. The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease. Molecules. 2016 Sep;21(9).
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Srikanthan K, Feyh A, Visweshwar H, Shapiro JI, Sodhi K. 2016. Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population. Int J Med Sci. 2016 10 22;13(1):25-38.
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Sodhi K, Puri N, Favero G, Stevens S, Meadows C, Abraham NG, Rezzani R, Ansinelli H, Lebovics E, Shapiro JI. 2016. Fructose Mediated Non-Alcoholic Fatty Liver Is Attenuated by HO-1-SIRT1 Module in Murine Hepatocytes and Mice Fed a High Fructose Diet. PLoS ONE. 2016 5 5;10(6):e0128648.
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Liu J, Tian J, Chaudhry M, Maxwell K, Yan Y, Wang X, Shah PT, Khawaja AA, Martin R, Robinette TJ, El-Hamdani A, Dodrill MW, Sodhi K, Drummond CA, Haller ST, Kennedy DJ, Abraham NG, Xie Z, Shapiro JI.. 2016. Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates Experimental Uremic Cardiomyopathy. Sci Rep. Sci Rep. 2016 Oct 4;6:34592. doi: 10.1038/srep34592
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Peterson SJ, Vanella L, Gotlinger K, Jiang H, Singh SP, Sodhi K, Maher E, O'Hanlon K, Shapiro JI, Abraham NG.. 2016. Oxidized HDL is a potent inducer of adipogenesis and causes activation of the Ang-II and 20-HETE systems in human obese females. Prostaglandins Other Lipid Mediat. 2016 Mar;123:68-77. doi: 10.1016/j.prostaglandins.2016.04.004. Review
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Waldman M, Bellner L, Vanella L, Schragenheim J, Sodhi K, Singh SP, Lin D, Lakhkar A, Li J, Hochhauser E, Arad M, Darzynkiewicz Z, Kappas A, Abraham NG.. 2016. Epoxyeicosatrienoic Acids Regulate Adipocyte Differentiation of Mouse 3T3 Cells, Via PGC-1a Activation, Which Is Required for HO-1 Expression and Increased Mitochondrial Function. Stem Cells Dev. Stem Cells Dev. 2016 Jul 15;25(14):1084-94. doi: 10.1089/scd.2016.0072
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Sodhi K, Bracero L, Feyh A, Nichols A, Srikanthan K, Latif T, Preston D, Shapiro JI, Elitsur Y.. 2016. Role of Serum Biomarkers in Early Detection of Non-Alcoholic Steatohepatitis and Fibrosis in West Virginian Children. J Clin Cell Immunol. J Clin Cell Immunol. 2016 Feb;7(1). pii: 393
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Shah PT, Martin R, Sanabria J, Khitan Z, Santhanam P, Sodhi K, Abraham NG and Shapiro JI. 2016. Adiposity Predicts Pulse Pressure in Subjects with Chronic Kidney Disease: Data from the Modification of Diet in Renal Disease J Cardiol Curr Res 2016, 7(2): 00240

Srikanthan K, Shapiro JI, Sodhi K.. 2016. The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease. Molecules. 2016 Sep 3;21(9). pii: E1172. doi: 10.3390/molecules21091172. Review.
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Sodhi K, Hilgefort J, Banks G, Gilliam C, Stevens S, Ansinelli HA, Getty M, Abraham NG, Shapiro JI, Khitan Z. 2016. Uric Acid-Induced Adipocyte Dysfunction Is Attenuated by HO-1 Upregulation: Potential Role of Antioxidant Therapy to Target Obesity. Stem Cells Int. 2016 Nov;2016:8197325.
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Sodhi, K Hilgefort, J Banks, G Gilliam, C Stevens, S Ansinelli, HA Getty, M Abraham, NG Shapiro, JI Khitan, Z . 2016. Uric Acid-Induced Adipocyte Dysfunction Is Attenuated by HO-1 Upregulation: Potential Role of Antioxidant Therapy to Target Obesity Volume 2016 (2016), Article ID 8197325, 11 pages http://dx.doi.org/10.1155/2016/8197325

Sodhi K, Maxwell K, Yan Y, Liu J, Chaudhry MA, Getty M, Xie Z, Abraham NG, Shapiro JI. 2015. pNaKtide inhibits Na/K-ATPase reactive oxygen species amplification and attenuates adipogenesis. Sci Adv. 2015 11 26;1(9):e1500781.
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Cao J, Tsenovoy PL, Thompson EA, Falck JR, Touchon R, Sodhi K, Rezzani R, Shapiro JI, Abraham NG. 2015. Agonists of epoxyeicosatrienoic acids reduce infarct size and ameliorate cardiac dysfunction via activation of HO-1 and Wnt1 canonical pathway. Prostaglandins Other Lipid Mediat. 2015 Feb 9.
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Sodhi K, Pesce P, Stevens S, Puri N, Getty M, Hutcheson R, Sacerdoti D, and Shapiro J.. 2015. Impairment of Heme Oxygenase Expression in Immuno-suppressed Mice Exacerbates Ischemic Heart Myocytes Cell Death: Reversible by Bilirubin and Restoration of Nitric Oxide Journal of Cardiology and Therapy 2015; 2(2): 291-301

Pesce P, Cecchetto L, Brocco S, Bolognesi M, Sodhi K, Abraham NG, Sacerdoti D. 2015. Characterization of a murine model of cardiorenal syndrome type 1 by high-resolution Doppler sonography. J Ultrasound. 2015 Sep;18(3):229-35.
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Issan Y, Kornowski R, Aravot D, Shainberg A, Laniado-Schwartzman M, Sodhi K, Abraham NG, Hochhauser E. 2014. Heme Oxygenase-1 Induction Improves Cardiac Function following Myocardial Ischemia by Reducing Oxidative Stress. PLoS ONE. 2014 Mar;9(3):e92246.
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Hinds TD, Sodhi K, Meadows C, Fedorova L, Puri N, Kim DH, Peterson SJ, Shapiro J, Abraham NG, Kappas A. 2014. Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21. Obesity (Silver Spring). 2014 11 5;22(3):705-12.
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Sodhi K, Puri N, Kim DH, Hinds TD, Stechschulte LA, Favero G, Rodella L, Shapiro JI, Jude D, Abraham NG. 2014. PPARd binding to heme oxygenase 1 promoter prevents angiotensin II-induced adipocyte dysfunction in Goldblatt hypertensive rats. Int J Obes (Lond). 2014 12 15;38(3):456-65.
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Khitan Z, Harsh M, Sodhi K, Shapiro JI, Abraham NG. 2014. HO-1 Upregulation Attenuates Adipocyte Dysfunction, Obesity, and Isoprostane Levels in Mice Fed High Fructose Diets. J Nutr Metab. 2014 Sep;2014:980547.
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Abraham NG, Sodhi K, Silvis AM, Vanella L, Favero G, Rezzani R, Lee C, Zeldin DC, Schwartzman ML. 2014. CYP2J2 Targeting to Endothelial Cells Attenuates Adiposity and Vascular Dysfunction in Mice Fed a High-Fat Diet by Reprogramming Adipocyte Phenotype. Hypertension. 2014 Sep 22.
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Vanella L, Sodhi K, Kim DH, Puri N, Maheshwari M, Hinds TD, Bellner L, Goldstein D, Peterson SJ, Shapiro JI, Abraham NG. 2013. Increased heme-oxygenase 1 expression decreases adipocyte differentiation and lipid accumulation in mesenchymal stem cells via upregulation of the canonical Wnt signaling cascade. Stem Cell Res Ther. 2013 Mar 12;4(2):28.
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Fedorova LV, Sodhi K, Gatto-Weis C, Puri N, Hinds TD, Shapiro JI, Malhotra D. 2013. Peroxisome proliferator-activated receptor d agonist, HPP593, prevents renal necrosis under chronic ischemia. PLoS ONE. 2013 May;8(5):e64436.
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Monu SR, Pesce P, Sodhi K, Boldrin M, Puri N, Fedorova L, Sacerdoti D, Peterson SJ, Abraham NG, Kappas A. 2013. HO-1 induction improves the type-1 cardiorenal syndrome in mice with impaired angiotensin II-induced lymphocyte activation. Hypertension. 2013 10 1;62(2):310-6.
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Kim DH, Puri N, Sodhi K, Falck JR, Abraham NG, Shapiro J, Schwartzman ML. 2013. Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes. J. Lipid Res. 2013 Mar;54(3):786-93.
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Puri N, Zhang F, Monu SR, Sodhi K, Bellner L, Lamon BD, Zhang Y, Abraham NG, Nasjletti A. 2013. Antioxidants Condition Pleiotropic Vascular Responses to Exogenous H(2)O(2): Role of Modulation of Vascular TP Receptors and the Heme Oxygenase System. Antioxid. Redox Signal. 2013 Feb 10;18(5):471-80.
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Cao J, Puri N, Sodhi K, Bellner L, Abraham NG, Kappas A. 2012. Apo A1 Mimetic Rescues the Diabetic Phenotype of HO-2 Knockout Mice via an Increase in HO-1 Adiponectin and LKBI Signaling Pathway. Int J Hypertens. 2012 Apr;2012:628147.
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Kawakami T, Puri N, Sodhi K, Bellner L, Takahashi T, Morita K, Rezzani R, Oury TD, Abraham NG. 2012. Reciprocal Effects of Oxidative Stress on Heme Oxygenase Expression and Activity Contributes to Reno-Vascular Abnormalities in EC-SOD Knockout Mice. Int J Hypertens. 2012 Jan;2012:740203.
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Puri N, Sodhi K, Haarstad M, Kim DH, Bohinc S, Foglio E, Favero G, Abraham NG. 2012. Heme induced oxidative stress attenuates sirtuin1 and enhances adipogenesis in mesenchymal stem cells and mouse pre-adipocytes. J. Cell. Biochem. 2012 Jun;113(6):1926-35.
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Cao J, Peterson SJ, Sodhi K, Vanella L, Barbagallo I, Rodella LF, Schwartzman ML, Abraham NG, Kappas A. 2012. Heme oxygenase gene targeting to adipocytes attenuates adiposity and vascular dysfunction in mice fed a high-fat diet. Hypertension. 2012 Aug;60(2):467-75.
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Sodhi K, Puri N, Inoue K, Falck JR, Schwartzman ML, Abraham NG. 2012. EET agonist prevents adiposity and vascular dysfunction in rats fed a high fat diet via a decrease in Bach 1 and an increase in HO-1 levels. Prostaglandins Other Lipid Mediat. 2012 Aug;98(3-4):133-42.
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Cao J, Inoue K, Sodhi K, Puri N, Peterson SJ, Rezzani R, Abraham NG. 2012. High-fat diet exacerbates renal dysfunction in SHR: reversal by induction of HO-1-adiponectin axis. Obesity (Silver Spring). 2012 May;20(5):945-53.
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Cao J, Sodhi K, Puri N, Monu SR, Rezzani R, Abraham NG. 2011. High fat diet enhances cardiac abnormalities in SHR rats: Protective role of heme oxygenase-adiponectin axis. Diabetol Metab Syndr. 2011 Dec;3(1):37.
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Cao J, Sodhi K, Inoue K, Quilley J, Rezzani R, Rodella L, Vanella L, Germinario L, Stec DE, Abraham NG, Kappas A. 2011. Lentiviral-human heme oxygenase targeting endothelium improved vascular function in angiotensin II animal model of hypertension. Hum. Gene Ther. 2011 Mar;22(3):271-82.
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Vanella L, Kim DH, Sodhi K, Barbagallo I, Burgess AP, Falck JR, Schwartzman ML, Abraham NG. 2011. Crosstalk between EET and HO-1 downregulates Bach1 and adipogenic marker expression in mesenchymal stem cell derived adipocytes. Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):54-62.
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Sodhi K, Wu CC, Cheng J, Gotlinger K, Inoue K, Goli M, Falck JR, Abraham NG, Schwartzman ML. 2010. CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent. Hypertension. 2010 Nov;56(5):871-8.
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Burgess A, Li M, Vanella L, Kim DH, Rezzani R, Rodella L, Sodhi K, Canestraro M, Martasek P, Peterson SJ, Kappas A, Abraham NG. 2010. Adipocyte heme oxygenase-1 induction attenuates metabolic syndrome in both male and female obese mice. Hypertension. 2010 Dec;56(6):1124-30.
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Addabbo F, Ratliff B, Park HC, Kuo MC, Ungvari Z, Csiszar A, Ciszar A, Krasnikov B, Krasnikof B, Sodhi K, Zhang F, Nasjletti A, Goligorsky MS. 2009. The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach. Am. J. Pathol. 2009 Jan;174(1):34-43.
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Inoue K, Sodhi K, Puri N, Gotlinger KH, Cao J, Rezzani R, Falck JR, Abraham NG, Laniado-Schwartzman M. 2009. Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE. Am. J. Physiol. Renal Physiol. 2009 Oct;297(4):F875-84.
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Sodhi K, Inoue K, Gotlinger KH, Canestraro M, Vanella L, Kim DH, Manthati VL, Koduru SR, Falck JR, Schwartzman ML, Abraham NG. 2009. Epoxyeicosatrienoic acid agonist rescues the metabolic syndrome phenotype of HO-2-null mice. J. Pharmacol. Exp. Ther. 2009 Dec;331(3):906-16.
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Hinds, TD, Sodhi, M, Meadows, C, Fedorova, L, Puri, N, Kim, DH, Peterson, S, Shapiro, J, Abraham, NG, Kappas, A. Terry D. Hinds, Jr.*+, Komal Sodhi1*, Charles Meadows1, Larisa Fedorova+, Nitin Puri+, Dong Hyun Kim1, Stephen J. Peterson2 Joseph Shapiro1, Nader G. Abraham1,3 and Attallah Kappas3 . . Increased HO-1 Levels Ameliorate the Development of Fatty Liver Via Reduction of Heme and Recruitment of FGF21