Joseph I. Shapiro, MD

Professor
Dean, Marshall University Joan C. Edwards School of Medicine

Departments

Clinical Interests

Hospital Privileges

Biography

Dr. Shapiro specializes in renal transplant, chronic dialysis, hypertension and diseases of the kidney.

Education & Training

  • Medical School: University of Medicine and Dentistry of New Jersey, New Jersey Medical School (Newark, N.J.)
  • Residency: Georgetown University (Washington, D.C.)
  • Fellowship: University of Colorado - Renal Diseases (Aurora, Colo.)

Honors & Memberships

  • Albert Nelson Marquis Lifetime Achievement Award, Who's Who
  • America's Top Doctor since 2012, Castle Connolly
  • Fellow, Society of Magnetic Resonance in Medicine
  • Fellow, American Heart Association
  • Fellow, American College of Physicians
  • Fellow, American Society of Nephrology
  • Master , American College of Physicians (ACP)
  • Member, International Society of Nephrology
  • Member, Colorado Society of Nephrology
  • Member, American Association for the Advancement of Science
  • Member, Association of Professors of Medicine
  • Member, Association of Program Directors in Internal Medicine
  • Member, Phi Kappa Phi Honor Society
  • Member, American Physiological Society - Cardiovascular Section
  • Member, Alpha Omega Alpha Honor Medical Society
  • Member, Western Society for Clinical Investigation
  • Member, Central Society for Clinical Investigation
  • Member, American Society of Nephrology, Hypertension and Kidney Disease

Certification

  • Certified: American Board of Internal Medicine, subspecialty certification in Nephrology

Marshall Kidney & Hypertension Center

An outpatient department of Cabell Huntington Hospital
J. Robert Pritchard Dialysis Center
1690 Medical Center Drive
Huntington, WV 25701
Phone: 304-526-2532

Map & Directions


. 2020. Adipocyte Specific HO-1 Gene Therapy is Effective in Antioxidant Treatment of Insulin Resistance and Vascular Function in an Obese Mice Model Antioxidants 2020, 9, 40; doi:10.3390/antiox9010040

Shailendra P. Singh Menachem Greenberg Yosef Glick Lars Bellner Gaia Favero Rita Rezzani Luigi Fabrizio Rodella Kevin Agostinucci Joseph I. Shapiro Nader G. Abraham. 2020. Adipocyte Specific HO-1 Gene Therapy is Effective in Antioxidant Treatment of Insulin Resistance and Vascular Function in an Obese Mice Model Antioxidants 2020, 9, 40; doi:10.3390/antiox9010040

Shailendra P. Singh Menachem Greenberg Yosef Glick Lars Bellner Gaia Favero Rita Rezzani Luigi Fabrizio Rodella Kevin Agostinucci Joseph I. Shapiro Nader G. Abraham. 2020. Adipocyte Specific HO-1 Gene Therapy is Effective in Antioxidant Treatment of Insulin Resistance and Vascular Function in an Obese Mice Model Antioxidants 2020, 9, 40; doi:10.3390/antiox9010040
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Liu J, Nie Y, Chaudhry M, Bai F, Chuang J, Sodhi K, Shapiro JI. 2020. The Redox-Sensitive Na/K-ATPase Signaling in Uremic Cardiomyopathy. Int J Mol Sci. 2020 2 20;21(4).
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Wang X, Cai L, Xie JX, Cui X, Zhang J, Wang J, Chen Y, Larre I, Shapiro JI, Pierre SV, Wu D, Zhu GZ, Xie Z. 2020. A caveolin binding motif in Na/K-ATPase is required for stem cell differentiation and organogenesis in mammals and C.elegans. Sci Adv. 2020 6 17;6(22):eaaw5851.
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Alsanani A, Shapiro JI. 2020. Effects of Short-Term Proteinuria on the Incidence of Stroke in Patients With Different Glucose Tolerance Status. J Am Heart Assoc. 2020 6 17;e017288.
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Sodhi K, Wang X, Chaudhry MA, Lakhani HV, Zehra M, Pratt R, Nawab A, Cottrill CL, Snoad B, Bai F, Denvir J, Liu J, Sanabria JR, Xie Z, Abraham NG, Shapiro JI. 2020. Central Role for Adipocyte Na,K-ATPase Oxidant Amplification Loop in the Pathogenesis of Experimental Uremic Cardiomyopathy. J. Am. Soc. Nephrol. 2020 6 27.
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Fakhouri EW, Peterson SJ, Kothari J, Alex R, Shapiro JI, Abraham NG. 2020. Genetic Polymorphisms Complicate COVID-19 Therapy: Pivotal Role of HO-1 in Cytokine Storm. Antioxidants (Basel). 2020 7 28;9(7).
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Sodhi K, Denvir J, Liu J, Sanabria JR, Chen Y, Silverstein R, Xie Z, Abraham NG, Shapiro JI. 2020. Oxidant-Induced Alterations in the Adipocyte Transcriptome: Role of the Na,K-ATPase Oxidant Amplification Loop 2020 Aug 18;21(16):5923.

Gress TW, Mansoor K, Rayyan YM, Khthir RA, Tayyem RF, Tzamaloukas AH, Abraham NG, Shapiro JI, Khitan ZJ. 2020. Relationship between dietary sodium and sugar intake: A cross-sectional study of the National Health and Nutrition Examination Survey 2001-2016. J Clin Hypertens (Greenwich). 2020 8 8.
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Tun S, Spainhower CJ, Cottrill CL, Lakhani HV, Pillai SS, Dilip A, Chaudhry H, Shapiro JI, Sodhi K. 2020. Therapeutic Efficacy of Antioxidants in Ameliorating Obesity Phenotype and Associated Comorbidities. Front Pharmacol. 2020 9 10;11:1234.
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Wang X, Shapiro JI. 2019. Evolving concepts in the pathogenesis of uraemic cardiomyopathy. Nat Rev Nephrol. 2019 1 22.
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Chen T, Brewster P, Tuttle KR, Dworkin LD, Henrich W, Greco BA, Steffes M, Tobe S, Jamerson K, Pencina K, Massaro JM, D'Agostino RB, Cutlip DE, Murphy TP, Cooper CJ, Shapiro JI. 2019. Prediction of cardiovascular outcomes with machine learning techniques: application to the Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL) study. Int J Nephrol Renovasc Dis. 2019 4 10;12:49-58.
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Pratt RD, Brickman C, Nawab A, Cottrill C, Snoad B, Lakhani HV, Jelcick A, Henderson B, Bhardwaj NN, Sanabria JR, Liu J, Xie Z, Abraham NG, Shapiro JI, Sodhi K. 2019. The Adipocyte Na/K-ATPase Oxidant Amplification Loop is the Central Regulator of Western Diet-Induced Obesity and Associated Comorbidities. Sci Rep. 2019 5 30;9(1):7927.
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Cooper CJ, Wehner P, Dailey C, O'Connor N, Kleshinski J, Shapiro JI. 2019. Information within residency monthly evaluation forms at two institutions. Med Educ Online. 2019 6 28;24(1):1635844.
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Lakhani HV, Zehra M, Pillai SS, Puri N, Shapiro JI, Abraham NG, Sodhi K. 2019. Beneficial Role of HO-1-SIRT1 Axis in Attenuating Angiotensin II-Induced Adipocyte Dysfunction. Int J Mol Sci. 2019 7 3;20(13).
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Yan Y, Wang J, Chaudhry MA, Nie Y, Sun S, Carmon J, Shah PT, Bai F, Pratt R, Brickman C, Sodhi K, Kim JH, Pierre S, Malhotra D, Rankin GO, Xie ZJ, Shapiro JI, Liu J. 2019. Metabolic Syndrome and Salt-Sensitive Hypertension in Polygenic Obese TALLYHO/JngJ Mice: Role of Na/K-ATPase Signaling. Int J Mol Sci. 2019 7 19;20(14).
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Singh SP, McClung JA, Thompson E, Glick Y, Greenberg M, Acosta-Baez G, Edris B, Shapiro JI, Abraham NG. 2019. Cardioprotective Heme Oxygenase-1-PGC1a Signaling in Epicardial Fat Attenuates Cardiovascular Risk in Humans as in Obese Mice. Obesity (Silver Spring). 2019 8 24.
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Cooper EL, Xie Y, Nguyen H, Brewster PS, Sholl H, Sharrett M, Ren K, Chen T, Tuttle KR, Haller ST, Jamerson K, Murphy TP, D'Agostino RB, Massaro JM, Henrich W, Cooper CJ, Cutlip DE, Dworkin LD, Shapiro JI. 2019. Early Rapid Decline in Kidney Function in Medically Managed Patients With Atherosclerotic Renal Artery Stenosis. J Am Heart Assoc. 2019 8 23;8(11):e012366.
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Tzamaloukas AH, Khitan ZJ, Glew RH, Roumelioti ME, Rondon-Berrios H, Elisaf MS, Raj DS, Owen J, Sun Y, Siamopoulos KC, Rohrscheib M, Ing TS, Murata GH, Shapiro JI, Malhotra D. 2019. Serum Sodium Concentration and Tonicity in Hyperglycemic Crises: Major Influences and Treatment Implications. J Am Heart Assoc. 2019 9 25;8(19):e011786.
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Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding PJ, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, Malarkannan S, Sodhi K, Shapiro JI, Xie Z, Sahoo D, Silverstein RL. 2019. Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses. Circ. Res. 2019 10 19.
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Peterson S, Thompson E, Liu L, Weingarten J, O’Hanlon K, Bhesania S, Bialczak A, Shapiro J, Abraham N.. 2019. Adipokines and Endothelial Dysfunction: A Potential Biomarker Profile for Cardiovascular Risk in Women with Obesity. 2019Jan,27(1)

Peterson S, Thompson E, Liu L, Weingarten J, O’Hanlon K, Bhesania S, Bialczak A, Shapiro J, Abraham N.. 2019. Adipokines and Endothelial Dysfunction: A Potential Biomarker Profile for Cardiovascular Risk in Women with Obesity. 2019Jan,27(1)

Lakhani HV, Khanal T, Gabi A, Yousef G, Alam MB, Sharma D, Aljoudi H, Puri N, Thompson E, Shapiro JI, Sodhi K. 2019. Developing a panel of biomarkers and miRNA in patients with myocardial infarction for early intervention strategies of heart failure in West Virginian population. PLoS ONE. 2019 3 21;13(10):e0205329.
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Bartlett DE, Miller RB, Thiesfeldt S, Lakhani HV, Khanal T, D Pratt R, Cottrill CL, Klug RL, Adkins NS, Bown PC, Nease DB, Shapiro JI, Sodhi K. 2018. Uremic Toxins Activates Na/K-ATPase Oxidant Amplification Loop Causing Phenotypic Changes in Adipocytes in In Vitro Models. Int J Mol Sci. 2018 12 26;19(9).
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Pratt RD, Brickman CR, Cottrill CL, Shapiro JI, Liu J. 2018. The Na/K-ATPase Signaling: From Specific Ligands to General Reactive Oxygen Species. Int J Mol Sci. 2018 9 12;19(9).
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Grigorova YN, Wei W, Petrashevskaya N, Zernetkina V, Juhasz O, Fenner R, Gilbert C, Lakatta EG, Shapiro JI, Bagrov AY, Fedorova OV. 2018. Dietary Sodium Restriction Reduces Arterial Stiffness, Vascular TGF-ß-Dependent Fibrosis and Marinobufagenin in Young Normotensive Rats. Int J Mol Sci. 2018 10 18;19(10).
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Wang W, Shapiro JI. 2018. Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase. Int J Mol Sci. 2018 8 12;19(8).
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Bartlett DE, Miller RB, Thiesfeldt S, Lakhani HV, Shapiro JI, Sodhi K. 2018. The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Aging: Implications in Obesity and Cardiovascular Disease. Int J Mol Sci. 2018 7 26;19(7).
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Gress TW Denvir J Shapiro JI. 2018. Effect of Removing Outliers on Statistical Inference: Implications to Interpretation of Experimental Data in Medical Research Vol. 4: Iss. 2, Article 9. DOI: http://dx.doi.org/10.18590/mjm.2018.vol4.iss2.9

Roumelioti M Glew RH Khitan ZJ Rondon-Berrios H Argyropoulos CP Malhotra D Raj DJ Agaba EI Rohrscheib M Murata GH Shapiro JI Tzamaloukas AH. 2018. Fluid balance concepts in medicine: Principles and practice World J Nephrol 7(1):1-28. 2018.

Khitan ZJ, Tzamaloukas AH, Brodsky S, Shapiro JI. 2018. Dihydropyridine calcium channel blockers in the elderly with diabetic nephropathy: Are they safe? J Clin Hypertens (Greenwich). 2018 1 10.
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Liu J, Lilly MN, Shapiro JI. 2018. Targeting Na/K-ATPase Signaling: A New Approach to Control Oxidative Stress. Curr. Pharm. Des. 2018 1 11.
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Khitan ZJ, Shweihat YR, Tzamaloukas AH, Shapiro JI. 2018. Dietary potassium and cardiovascular profile. Results from the modification of diet in renal disease dataset. J Clin Hypertens (Greenwich). 2018 2 20.
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Ogu I, Shweihat YR, Shapiro JI, Khitan ZJ. 2018. Stroke volume and proteinuria in obesity-related glomerulopathy: potential role in pathogenesis and choice of antihypertensive regimen. J Clin Hypertens (Greenwich). 2018 2 16.
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Roumelioti ME, Ing TS, Rondon-Berrios H, Glew RH, Khitan ZJ, Sun Y, Malhotra D, Raj DS, Agaba EI, Murata GH, Shapiro JI, Tzamaloukas AH. 2018. Principles of quantitative water and electrolyte replacement of losses from osmotic diuresis. Int Urol Nephrol. 2018 3 8.
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Khitan ZJ, Kheetan MM, Shapiro JI. 2018. PURE is not so pure when it comes to dietary sodium and cardiovascular events! J Clin Hypertens (Greenwich). 2018 4 1.
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Sodhi K, Nichols A, Mallick A, Klug RL, Liu J, Wang X, Srikanthan K, Goguet-Rubio P, Nawab A, Pratt R, Lilly MN, Sanabria JR, Xie Z, Abraham NG, Shapiro JI. 2018. The Na/K-ATPase Oxidant Amplification Loop Regulates Aging. Sci Rep. 2018 6 28;8(1):9721.
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Peterson SJ, Shapiro JI, Thompson E, Singh S, Liu L, Weingarten JA, O'Hanlon K, Bialczak A, Bhesania SR, Abraham NG. 2018. Oxidized HDL, Adipokines, and Endothelial Dysfunction: A Potential Biomarker Profile for Cardiovascular Risk in Women with Obesity. Obesity (Silver Spring). 2018 12 21;27(1):87-93.
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Lakhani HV, Sharma D, Dodrill MW, Nawab A, Sharma N, Cottrill CL, Shapiro JI, Sodhi K. 2018. Phenotypic Alteration of Hepatocytes in Non-Alcoholic Fatty Liver Disease. Int J Med Sci. 2018 12 28;15(14):1591-1599.
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Sodhi K Srikanthan K Goguet-Rubio P Nichols A Mallick A Nawab A Martin R Shah PT Chaudhry M Sigdel S El-Hamdani M Liu J Xie Z Abraham NG Shapiro JI. 2017. pNaKtide Attenuates Steatohepatitis and Atherosclerosis by Blocking Na/K-ATPase/ROS Amplification in C57Bl6 and ApoE Knockout Mice Fed a Western Diet SCI REP-UK 2017 Mar 15;7(1):193
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Shapiro JI. 2017. Education of Nurse Practitioners and Physician Assistants; What Role, if any, for Physicians in Determining Their Scope of Practice? Marshall Journal of Medicine: Vol. 3: Iss. 1, Article 3.

Santhanam P, Shapiro JI, Khitan Z. 2017. Association between dietary potassium, body mass index, and proteinuria in normotensive and hypertensive individuals: Results from the Modification of Diet in Renal Disease study baseline data. J Clin Hypertens (Greenwich). 2017 4 4;19(5):558-559.
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Drummond CA, Brewster PS, He W, Ren K, Xie Y, Tuttle KR, Haller ST, Jamerson K, Dworkin LD, Cutlip DE, Murphy TP, D'Agostino RB Sr, Henrich WL, Tian J, Shapiro JI, Cooper CJ.. 2017. Cigarette smoking and cardio-renal events in patients with atherosclerotic renal artery stenosis. PLoS ONE. PLoS One. 2017 Mar 17;12(3):e0173562. doi: 10.1371/journal.pone.0173562.
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Goguet-Rubio, P, Klug, R.L., Lakhani, V.H, Nichols, A, Dana L. Sharma, D.L., Srikanthan, K., Puri, N. O’Hanlon, K.M.,Shapiro JI. 2017. Existence of a Strong Correlation of Biomarkers and miRNA in Females with Metabolic Syndrome and Obesity in a Population of West Virginia. Int J Med Sci. 2017 Mar
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Wang X, Liu J, Drummond, CA, and Shapiro JI. 2017. Sodium potassium adenosine triphosphatase (Na/K-ATPase) as a therapeutic target for uremic cardiomyopathy EXPERT OPIN THER TAR Expert Opinion on Therapeutic Targets. 2017 May; 21(5):531-541
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Alaini A, Malhotra D, Rondon-Berrios H, Argyropoulos CP, Khitan ZJ, Raj DSC, Rohrscheib M, Shapiro JI, Tzamaloukas AH. 2017. Establishing the presence or absence of chronic kidney disease: uses and limiations of formualas estimating the glomerular filtration rate World J Methodol 2017 7:73-92

Sharma DL, Lakhani HV, Klug RL, Snoad B, El-Hamdani R, Shapiro JI, Sodhi K. 2017. Investigating Molecular Connections of Non-alcoholic Fatty Liver Disease with Associated Pathological Conditions in West Virginia for Biomarker Analysis. J Clin Cell Immunol. 2017 11 28;8(5).
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Xie JX Zhang S Cui X Zhang J Yu H Khalaf FK Malhotra D Kennedy DJ Shapiro JI Tian J Haller ST. 2017. Na/K-ATPase/src complex mediates regulation of CD40 in renal parenchyma Nephrology Dialysis Transplantation, 2017 , gfx334, https://doi.org/10.1093/ndt/gfx334
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Mansoor K, Kheetan M, Shahnawaz S, Shapiro AP, Patton-Tackett E, Dial L, Rankin G, Santhanam P, Tzamaloukas AH, Nadasdy T, Shapiro JI, Khitan ZJ. 2017. Systematic review of nephrotoxicity of drugs of abuse, 2005-2016. BMC Nephrol. 2017 12 31;18(1):379.
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Wang X, Chaudhry MA, Nie Y, Xie Z, Shapiro JI, Liu J. 2017. A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy. J Vis Exp. 2017 11 21;(129).
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Ogu I, Surindran S, Shapiro JI. 2017. Hyponatremia in Hypothyroid Disorders: Current Understanding. • Ogu I, Surindran S, Shapiro JI (2017) Hyponatremia in Hypothyroid Disorders: Current Understanding. JSM Thyroid Disord Manag 2(2):1014.

Cao J, Singh SP, McClung JA, Joseph G, Vanella L, Barbagallo I, Jiang H, Falck JR, Arad M, Shapiro JI, Abraham NG. 2017. EET intervention on Wnt1, NOV, and HO-1 signaling prevents obesity-induced cardiomyopathy in obese mice. Am. J. Physiol. Heart Circ. Physiol. 2017 6 4;313(2):H368-H380.
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Khitan ZJ, Shapiro JI. 2017. The Association between HDL-C and Hyponatremia. is There Something Else Low? Am. J. Med. 2017 7 22.
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Loudin S, Werthammer J, Prunty L, Murray S, Shapiro JI, Davies TH. 2017. A management strategy that reduces NICU admissions and decreases charges from the front line of the neonatal abstinence syndrome epidemic. J Perinatol. 2017 7 7.
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Liu J, Yan Y, Nie Y, Shapiro JI.. 2017. Na/K-ATPase Signaling and Salt Sensitivity: The Role of Oxidative Stress. Antioxidants (Basel). Antioxidants.2017, 6(1), 18;
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Nawab A, Nichols A, Klug R, Shapiro JI, Sodhi K. 2017. Spin Trapping: A Review for the Study of Obesity Related Oxidative Stress and Na(+)/K(+)-ATPase. J Clin Cell Immunol. 2017 8 18;8(3).
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KhitanZ , Shapiro A, Shah PT, Sanabria JR, Santhanam P, Sodhi, Abraham NG, Shapiro JI. 2017. Predicting Adverse Outcomes in Chronic Kidney Disease Using Machine Learning Methods: Data from the Modification of Diet in Renal Disease Marshall Journal of Medicine: Vol. 3: Iss. 4, Article 10.

Rondon-Berrios H Argyropoulos C Ing TS Raj DS Malhotra D Agaba EI Rohrscheib M Khitan ZJ Murata GH Shapiro JI Tzamaloukas AH. . 2017. Hypertonicity: Clinical entities, manifestations and treatment. World J Nephrol. World J Nephrol. 2017 Jan 6;6(1):1-13.
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Alaini A Malhotra D Rondon-Berrios H Argyropoulos C Khitan ZJ Raj D Rohrscheib M Shapiro JI Tzamaloukas AH. 2017. Cigarette smoking causes epigenetic changes associated with cardiorenal fibrosis. Physiol. Genomics. World Journal of Methodology: In Press
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Shapiro JI. 2017. Education of Nurse Practitioners and Physician Assistants; What Role, if any, for Physicians in Determining Their Scope of Practice? Marshall Journal of Medicine: Vol. 3: Iss. 1, Article 3.

Srikanthan K, Shapiro JI, Sodhi K.. 2016. The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease. Molecules. 2016 Sep 3;21(9). pii: E1172. doi: 10.3390/molecules21091172. Review.
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Sodhi K, Hilgefort J, Banks G, Gilliam C, Stevens S, Ansinelli HA, Getty M, Abraham NG, Shapiro JI, Khitan Z. 2016. Uric Acid-Induced Adipocyte Dysfunction Is Attenuated by HO-1 Upregulation: Potential Role of Antioxidant Therapy to Target Obesity. Stem Cells Int. 2016 Nov;2016:8197325.
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Sodhi K, Puri N, Favero G, Stevens S, Meadows C, Abraham NG, Rezzani R, Ansinelli H, Lebovics E, Shapiro JI. 2016. Fructose Mediated Non-Alcoholic Fatty Liver Is Attenuated by HO-1-SIRT1 Module in Murine Hepatocytes and Mice Fed a High Fructose Diet. PLoS ONE. 2016 5 5;10(6):e0128648.
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Shah PT, Martin R, Sanabria J, Khitan Z, Santhanam P, Sodhi K, Abraham NG and Shapiro JI. 2016. Adiposity Predicts Pulse Pressure in Subjects with Chronic Kidney Disease: Data from the Modification of Diet in Renal Disease J Cardiol Curr Res 2016, 7(2): 00240

Sodhi, K Hilgefort, J Banks, G Gilliam, C Stevens, S Ansinelli, HA Getty, M Abraham, NG Shapiro, JI Khitan, Z . 2016. Uric Acid-Induced Adipocyte Dysfunction Is Attenuated by HO-1 Upregulation: Potential Role of Antioxidant Therapy to Target Obesity Volume 2016 (2016), Article ID 8197325, 11 pages http://dx.doi.org/10.1155/2016/8197325

Argyropoulos C, Rondon-Berrios H, Raj DS, Malhotra D, Agaba EI, Rohrscheib M, Khitan Z, Murata GH, Shapiro JI, Tzamaloukas AH. 2016. Hypertonicity: Pathophysiologic Concept and Experimental Studies. Cureus. 2016 May;8(5):e596.
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Feyh A, Bracero L, Lakhani HV, Santhanam P, Shapiro JI, Khitan Z, Sodhi K. 2016. Role of Dietary Components in Modulating Hypertension. J Clin Exp Cardiolog. 2016 Apr;7(4).
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Yan Y, Shapiro JI. 2016. The physiological and clinical importance of sodium potassium ATPase in cardiovascular diseases. Curr Opin Pharmacol. 2016 12 15;27:43-9.
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Shah PT, Martin R, Yan Y, Shapiro JI, Liu J. 2016. Carbonylation Modification Regulates Na/K-ATPase Signaling and Salt Sensitivity: A Review and a Hypothesis. Front Physiol. 2016 Jun;7:256.
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Shaver A, Nichols A, Thompson E, Mallick A, Payne K, Jones C, Manne ND, Sundaram S, Shapiro JI, Sodhi K. 2016. Role of Serum Biomarkers in Early Detection of Diabetic Cardiomyopathy in the West Virginian Population. Int J Med Sci. 2016 Feb;13(3):161-8.
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Haller ST, Yan Y, Drummond CA, Xie J, Tian J, Kennedy DJ, Shilova VY, Xie Z, Liu J, Cooper CJ, Malhotra D, Shapiro JI, Fedorova OV, Bagrov AY.. 2016. Rapamycin Attenuates Cardiac Fibrosis in Experimental Uremic Cardiomyopathy by Reducing Marinobufagenin Levels and Inhibiting Downstream Pro-Fibrotic Signaling. J AM HEART ASSOC J Am Heart Assoc. 2016 Sep 30;5(10). pii: e004106.
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Shah PT, Martin R, Yan Y, Shapiro JI, Liu J.. 2016. Carbonylation Modification Regulates Na/K-ATPase Signaling and Salt Sensitivity : A Review and a Hypothesis. Front Physiol. 2016 Jun 28;7:256. doi: 10.3389/fphys.2016.00256. Review
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Drummond CA, Crotty Alexander LE, Haller ST, Fan X, Xie JX, Kennedy DJ, Liu J, Yan Y, Hernandez DA, Mathew DP, Cooper CJ, Shapiro JI, Tian J.. 2016. Cigarette smoking causes epigenetic changes associated with cardiorenal fibrosis. Physiol. Genomics. Physiol Genomics. 2016 Dec 1;48(12):950-960. doi: 10.1152/physiolgenomics.00070.2016.
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Liu J, Tian J, Chaudhry M, Maxwell K, Yan Y, Wang X, Shah PT, Khawaja AA, Martin R, Robinette TJ, El-Hamdani A, Dodrill MW, Sodhi K, Drummond CA, Haller ST, Kennedy DJ, Abraham NG, Xie Z, Shapiro JI.. 2016. Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates Experimental Uremic Cardiomyopathy. Sci Rep. Sci Rep. 2016 Oct 4;6:34592. doi: 10.1038/srep34592
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Peterson SJ, Vanella L, Gotlinger K, Jiang H, Singh SP, Sodhi K, Maher E, O'Hanlon K, Shapiro JI, Abraham NG.. 2016. Oxidized HDL is a potent inducer of adipogenesis and causes activation of the Ang-II and 20-HETE systems in human obese females. Prostaglandins Other Lipid Mediat. 2016 Mar;123:68-77. doi: 10.1016/j.prostaglandins.2016.04.004. Review
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Sodhi K, Bracero L, Feyh A, Nichols A, Srikanthan K, Latif T, Preston D, Shapiro JI, Elitsur Y.. 2016. Role of Serum Biomarkers in Early Detection of Non-Alcoholic Steatohepatitis and Fibrosis in West Virginian Children. J Clin Cell Immunol. J Clin Cell Immunol. 2016 Feb;7(1). pii: 393
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Khitan Z Shapiro JI. 2016. Role of Dietary Components in Modulating Hypertension. J Clin Exp Cardiolog. Renal and Electrolyte Disorders VIIth Edition ed by Robert W. Schrier, Little Brown, Boston
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Yan Y, Shapiro JI.. 2016. The physiological and clinical importance of sodium potassium ATPase in cardiovascular diseases. Curr Opin Pharmacol. 2016 Apr;27:43-9. doi: 10.1016/j.coph.2016.01.009.
View on PubMed

Drummond CA, Crotty Alexander LE, Haller ST, Fan X, Xie JX, Kennedy DJ, Liu J, Yan Y, Hernandez DA, Mathew DP, Cooper CJ, Shapiro JI, Tian J.. 2016. Cigarette smoking causes epigenetic changes associated with cardiorenal fibrosis. Physiol. Genomics. .Physiol Genomics. 2016 Dec 1;48(12):950-960.
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Srikanthan, K Feyh A Visweshwar H Shapiro JI Sodhi K. 2016. Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population Int J Med Sci 2016; 13(1):25-38. doi:10.7150/ijms.13800

Preeya T. Shah, Anna P. Shapiro, Zeid Khitan, Prasanna Santhanam, Joseph I. Shapiro. 2016. Why Does Obesity Lead to Hypertension? Further Lessons from the Intersalt Study. Shah, Preeya T.; Shapiro, Anna P.; Khitan, Zeid MD; Santhanam, Prasanna MD; and Shapiro, Joseph I. MD (2016) "Why Does Obesity Lead to Hypertension? Further Lessons from the Intersalt Study.," Marshall Journal of Medicine: Vol. 2: Iss. 1, Article 7

Argyropoulos C, Rondon-Berrios H, Raj DS, Malhotra D, Agaba EI, Rohrscheib M, Khitan Z, Murata GH, Shapiro JI, Tzamaloukas AH. 2016. Hypertonicity: Pathophysiologic Concept and Experimental Studies. Cureus. 2016 May;8(5):e596.
View on PubMed

Drummond CA, Hill MC, Shi H, Fan X, Xie JX, Haller ST, Kennedy DJ, Liu J, Garrett MR, Xie Z, Cooper CJ, Shapiro JI, Tian J.. 2016. Na/K-ATPase signaling regulates collagen synthesis through microRNA-29b-3p in cardiac fibroblasts. Physiol. Genomics. Physiol Genomics. 2016 Mar;48(3):220-9. doi: 10.1152/physiolgenomics.00116.2015
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Murphy TP, Cooper CJ, Pencina KM, D'Agostino R, Massaro J, Cutlip DE, Jamerson K, Matsumoto AH, Henrich W, Shapiro JI, Tuttle KR, Cohen DJ, Steffes M, Gao Q, Metzger DC, Abernethy WB, Textor SC, Briguglio J, Hirsch AT, Tobe S, Dworkin LD. 2016. Relationship of Albuminuria and Renal Artery Stent Outcomes: Results From the CORAL Randomized Clinical Trial (Cardiovascular Outcomes With Renal Artery Lesions). Hypertension. 2016 Sep 19.
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Peterson SJ, Vanella L, Gotlinger K, Jiang H, Singh SP, Sodhi K, Maher E, O'Hanlon K, Shapiro JI, Abraham NG. 2016. Oxidized HDL is a potent inducer of adipogenesis and causes activation of the Ang-II and 20-HETE systems in human obese females. Prostaglandins Other Lipid Mediat. 2016 May 11;123:68-77.
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Peterson SJ Vanella L Bialczak A Schragenheim J Li M Beliner L Shapiro JI Abraham NG. 2016. Oxidized HDL and isoprostane exert a potent adipogenic effect on stem cells: Where in the lineage? Cell, Stem Cells and Regenerative Medicine 2(1):doi Htt;://dx.doi.org/10.16966/csrm.109

Tuttle KR, Dworkin LD, Henrich W, Greco BA, Steffes M, Tobe S, Shapiro JI, Jamerson K, Lyass A, Pencina K, Massaro JM, D'Agostino RB, Cutlip DE, Murphy TP, Cooper CJ. 2016. Effects of Stenting for Atherosclerotic Renal Artery Stenosis on eGFR and Predictors of Clinical Events in the CORAL Trial. Clin J Am Soc Nephrol. 2016 Jul 7;11(7):1180-8.
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Haller ST, Kumarasamy S, Folt DA, Wuecher LM, Stepkowski S, Karamchandani M, Waghulde H, Mell B, Chaudhry M, Lessar K, Upadhyaya S, Drummond CA, Tian J, Filpiak WE, SAunders TL, Shapiro JI, Joe B, Cooper CJ. 2016. Targeted disruption of Cd40 in a genetically hypertensive rat model attenuates renal fibrosis and proteinuria, independent of blood pressure. Kidney Int. Kidney International 2016 Sep 28. pii: S0085-2538(16)30443-4. doi: 10.1016/j.kint.2016.08.015.
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Haller ST, Yan Y, Drummond CA, Xie J, Tian J, Kennedy DJ, Hilova VY, Xie Z, Liu J, Cooper CJ, Malhotra D, Shapiro JI, Fedorova OV, Bagrov AY. 2016. Rapamycin Attenuates Cardiac Fibrosis in Experimental Uremic Cardiomyopathy by Reducing Marinobufagenin Levels and Inhibiting Downstream Pro-fibrotic Signaling J Am Heart Assoc. 2016 Sep 30;5(10). pii: e004106.

Yan Y, Shapiro AP, Mopidevi BR, Chaudhry MA, Maxwell K, Haller ST, Drummond CA, Kennedy DJ, Tian J, Malhotra D, Xie ZJ, Shapiro JI, Liu J. 2016. Protein Carbonylation of an Amino Acid Residue of the Na/K-ATPase a1 Subunit Determines Na/K-ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells. J Am Heart Assoc. JAHA 2016 Sep;5(9).
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Srikanthan K, Shapiro JI, Sodhi K. 2016. The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease. Molecules. 2016 Sep;21(9).
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Srikanthan K, Feyh A, Visweshwar H, Shapiro JI, Sodhi K. 2016. Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population. Int J Med Sci. 2016 10 22;13(1):25-38.
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Yu S, Brewster P, Ren K, He W, Xiang K, Tuttle K, Jamerson K, Dworkin L, Cutlip D, Solomon S, Murphy T, Dagostino R, Henrich W, Shapiro J, Cooper C. 2015. STENTING OF ATHEROSCLEROTIC RENAL ARTERY STENOSIS DOES NOT IMPROVE CLINICAL OUTCOMES IN PATIENTS PRESENTING WITH CONGESTIVE HEART FAILURE, AN ANALYSIS OF THE CORAL TRIAL. J. Hypertens. 2015 Jun;33 Suppl 1:e49.
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Sodhi K, Maxwell K, Yan Y, Liu J, Chaudhry MA, Getty M, Xie Z, Abraham NG, Shapiro JI. 2015. pNaKtide inhibits Na/K-ATPase reactive oxygen species amplification and attenuates adipogenesis. Sci Adv. 2015 11 26;1(9):e1500781.
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Murphy TP, Cooper CJ, Matsumoto AH, Cutlip DE, Pencina KM, Jamerson K, Tuttle KR, Shapiro JI, D'Agostino R, Massaro J, Henrich W, Dworkin LD. 2015. Renal Artery Stent Outcomes: Effect of Baseline Blood Pressure, Stenosis Severity, and Translesion Pressure Gradient. J. Am. Coll. Cardiol. 2015 Dec 8;66(22):2487-94.
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Gullo, CG, McCarthy MJ, Shapiro JI, and Miller, B. 2015. Predicting Medical Student Success on Licensure Exams Predicting Medical Student Success on Licensure Exams. Gullo CG, McCarthy MJ, Shapiro, JI, and Miller B. Med Science Educator; 07 Oct. 2015; first online pp1-7.

Cao J, Tsenovoy PL, Thompson EA, Falck JR, Touchon R, Sodhi K, Rezzani R, Shapiro JI, Abraham NG. 2015. Agonists of epoxyeicosatrienoic acids reduce infarct size and ameliorate cardiac dysfunction via activation of HO-1 and Wnt1 canonical pathway. Prostaglandins Other Lipid Mediat. 2015 Feb 9.
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Sodhi K, Pesce P, Stevens S, Puri N, Getty M, Hutcheson R, Sacerdoti D, and Shapiro J.. 2015. Impairment of Heme Oxygenase Expression in Immuno-suppressed Mice Exacerbates Ischemic Heart Myocytes Cell Death: Reversible by Bilirubin and Restoration of Nitric Oxide Journal of Cardiology and Therapy 2015; 2(2): 291-301

Kyle Maxwell, Preeya Shah and Joseph I. Shapiro. 2015. The plasmalemmal Na/K-ATPase: an amplifier for reactive oxygen species? J Hypertension 4:100197 doi:10.4172/2167-1095,1000197.

Zeid Khitan MD, Deepak Malhotra MD PhD, Dominic S Raj MD, Antonios H. Tzamaloukas MD, and Joseph I Shapiro MD. 2015. Alkali Therapy in Lactic Acidosis Khitan,, Zeid J. MD; Malhotra,, Deepak MD; Raj,, Dominic S. MD; Tzamaloukas,, Antonios H. MD; and Shapiro,, Joseph I. MD (2015) "Alkali Therapy in Lactic Acidosis,"Marshall Journal of Medicine: Vol. 1: Iss. 1, Article 6.

Shah P, Maxwell K, Shapiro JI. 2015. Dashing away hypertension World J Hypertens. 4:119-128, 2015

Wehner P, Shapiro JI. 2014. Renal denervation to treat cardiac fibrosis? J Am Heart Assoc. 2014 Dec;3(6).
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Drummond CA, Buddny G, Haller ST, Liu J, Yan Y, Xie Z, Malhotra D, Shapiro JI, Tian J. 2014. Gender differences in the development of uremic cardiomyopathy following partial nephrectomy: Role of progesterone. J Hypertens (Los Angel). 2014 1 10;2.
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Hinds TD, Sodhi K, Meadows C, Fedorova L, Puri N, Kim DH, Peterson SJ, Shapiro J, Abraham NG, Kappas A. 2014. Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21. Obesity (Silver Spring). 2014 11 5;22(3):705-12.
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Sodhi K, Puri N, Kim DH, Hinds TD, Stechschulte LA, Favero G, Rodella L, Shapiro JI, Jude D, Abraham NG. 2014. PPARd binding to heme oxygenase 1 promoter prevents angiotensin II-induced adipocyte dysfunction in Goldblatt hypertensive rats. Int J Obes (Lond). 2014 12 15;38(3):456-65.
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Dial L, Liu J, Shapiro JI. 2014. Cardiotonic steroids in adaptation to dietary salt intake. Curr Clin Pharmacol. 2014;9(3):298-309.
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Yan Y, Shapiro AP, Haller S, Katragadda V, Liu L, Tian J, Basrur V, Malhotra D, Xie ZJ, Abraham NG, Shapiro JI, Liu J. 2014. Involvement of reactive oxygen species in a feed-forward mechanism of Na/K-ATPase-mediated signaling transduction. J. Biol. Chem. 2014 2 5;288(47):34249-58.
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Drummond CA, Sayed M, Evans KL, Shi H, Wang X, Haller ST, Liu J, Cooper CJ, Xie Z, Shapiro JI, Tian J. 2014. Reduction of Na/K-ATPase affects cardiac remodeling and increases c-kit cell abundance in partial nephrectomized mice. Am. J. Physiol. Heart Circ. Physiol. 2014 Jun 15;306(12):H1631-43.
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Haller ST, Drummond CA, Yan Y, Liu J, Tian J, Malhotra D, Shapiro JI. 2014. Passive immunization against marinobufagenin attenuates renal fibrosis and improves renal function in experimental renal disease. Am. J. Hypertens. 2014 12 15;27(4):603-9.
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Cooper CJ, Murphy TP, Cutlip DE, Jamerson K, Henrich W, Reid DM, Cohen DJ, Matsumoto AH, Steffes M, Jaff MR, Prince MR, Lewis EF, Tuttle KR, Shapiro JI, Rundback JH, Massaro JM, D'Agostino RB, Dworkin LD, CORAL Investigators. 2014. Stenting and medical therapy for atherosclerotic renal-artery stenosis. N. Engl. J. Med. 2014 Jan 2;370(1):13-22.
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Sun Y, Mills D, Ing TS, Shapiro JI, Tzamaloukas AH. 2014. Body sodium, potassium and water in peritoneal dialysis-associated hyponatremia. Perit Dial Int. 2014 May;34(3):253-9.
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Miller B, Dzwonek B, McGuffin A, Shapiro JI. 2014. From LCME Probation to Compliance: The Marshall University Joan C Edwards School of Medicine Experience

Xie JX, Shapiro AP, Shapiro JI. 2014. The Trade-Off between Dietary Salt and Cardiovascular Disease; A Role for Na/K-ATPase Signaling? Front Endocrinol (Lausanne). 2014 Jul;5:97.
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Miller B, Dzwonek B, McGuffin A, Shapiro JI. 2014. From LCME Probation to Compliance: The Marshall University Joan C Edwards School of Medicine Experience

Miller B, Dzwonek B, McGuffin A, Shapiro JI. 2014. From LCME probation to compliance: the Marshall University Joan C Edwards School of Medicine experience. Adv Med Educ Pract. 2014 Oct;5:377-82.
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Khitan Z, Harsh M, Sodhi K, Shapiro JI, Abraham NG. 2014. HO-1 Upregulation Attenuates Adipocyte Dysfunction, Obesity, and Isoprostane Levels in Mice Fed High Fructose Diets. J Nutr Metab. 2014 Sep;2014:980547.
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Dial L, Liu J, Shapiro JI. 2014. Cardiotonic steroids in adaptation to dietary salt intake. Curr Clin Pharmacol. 2014;9(3):298-309.
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Tzamaloukas AH, Shapiro JI, Raj DS, Murata GH, Glew RH, Malhotra D. 2014. Management of Severe Hyponatremia: Infusion of Hypertonic Saline and Desmopressin or Infusion of Vasopressin Inhibitors? Am. J. Med. Sci. 2014 Sep 22.
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Tzamaloukas AH, Malhotra D, Rosen BH, Raj DS, Murata GH, Shapiro JI. 2013. Principles of management of severe hyponatremia. J Am Heart Assoc. 2013 Feb;2(1):e005199.
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Haller ST, Kalra PA, Ritchie JP, Chrysochou T, Brewster P, He W, Yu H, Shapiro JI, Cooper CJ. 2013. Effect of CD40 and sCD40L on renal function and survival in patients with renal artery stenosis. Hypertension. 2013 Apr;61(4):894-900.
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Dial L, Liu J, Shapiro JI. 2013. The tradeoff between natriuresis and cardiac and renal fibrosis. Curr Clin Pharmacol. J Hypertension 2013 5: 1-16.
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Kennedy DJ, Chen Y, Huang W, Viterna J, Liu J, Westfall K, Tian J, Bartlett DJ, Tang WH, Xie Z, Shapiro JI, Silverstein RL. 2013. CD36 and Na/K-ATPase-a1 Form a Proinflammatory Signaling Loop in Kidney. Hypertension. 2013 Jan;61(1):216-24.
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Kim DH, Puri N, Sodhi K, Falck JR, Abraham NG, Shapiro J, Schwartzman ML. 2013. Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes. J. Lipid Res. 2013 Mar;54(3):786-93.
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Ahmed S, Shapiro JI. 2013. Obstructive Sleep Apnea and Hypertension 2013 Jul 6;

Murphy TP, Cooper CJ, Cutlip DE, Matsumoto A, Jamerson K, Rundback J, Rosenfield KA, Henrich W, Shapiro J, Massaro J, Yen CH, Burtch H, Thum C, Reid D, Dworkin L. 2013. Roll-in Experience from the Cardiovascular Outcomes with Renal Atherosclerotic Lesions (CORAL) Study. J Vasc Interv Radiol. 2013 Dec 7.
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Fedorova LV, Tamirisa A, Kennedy DJ, Haller ST, Budnyy G, Shapiro JI, Malhotra D. 2013. Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach. BMC Nephrol. 2013 Oct 4;14(1):209.
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Vanella L, Sodhi K, Kim DH, Puri N, Maheshwari M, Hinds TD, Bellner L, Goldstein D, Peterson SJ, Shapiro JI, Abraham NG. 2013. Increased heme-oxygenase 1 expression decreases adipocyte differentiation and lipid accumulation in mesenchymal stem cells via upregulation of the canonical Wnt signaling cascade. Stem Cell Res Ther. 2013 Mar 12;4(2):28.
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Tzamaloukas, AH, Y Sun, NK Konstantinov, TS Ing, RI Dorin, D Malhotra, GH Murata and JI Shapiro. 2013. Principles of quantitative fluid and cation replacement in extreme hyperglycemia. Cureus

Shapiro J. 2013. Simple acid-base disorders - Metabolic Acidosis book chapter

Fedorova LV, Sodhi K, Gatto-Weis C, Puri N, Hinds TD, Shapiro JI, Malhotra D. 2013. Peroxisome proliferator-activated receptor d agonist, HPP593, prevents renal necrosis under chronic ischemia. PLoS ONE. 2013 May;8(5):e64436.
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Joe B, Shapiro JI. 2012. Molecular mechanisms of experimental salt-sensitive hypertension. J Am Heart Assoc. 2012 Jun;1(3):e002121.
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Haller ST, Kennedy DJ, Shidyak A, Budny GV, Malhotra D, Fedorova OV, Shapiro JI, Bagrov AY. 2012. Monoclonal antibody against marinobufagenin reverses cardiac fibrosis in rats with chronic renal failure. Am. J. Hypertens. 2012 Jun;25(6):690-6.
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Gupta S, Yan Y, Malhotra D, Liu J, Xie Z, Najjar SM, Shapiro JI. 2012. Ouabain and insulin induce sodium pump endocytosis in renal epithelium. Hypertension. 2012 4 18;59(3):665-72.
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Yan Y, Haller S, Shapiro A, Malhotra N, Tian J, Xie Z, Malhotra D, Shapiro JI, Liu J. 2012. Ouabain-stimulated trafficking regulation of the Na/K-ATPase and NHE3 in renal proximal tubule cells. Mol. Cell. Biochem. 2012 10 16;367(1-2):175-83.
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Shapiro JI, Dial LD. 2012. How safe is unilateral nephrectomy? Hypertension. 2012 Dec;60(6):1383-4.
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Fedorova L, Gatto-Weis C, Smaili S, Khurshid N, Shapiro JI, Malhotra D, Horrigan T. 2012. Down-regulation of the transcription factor snail in the placentas of patients with preeclampsia and in a rat model of preeclampsia. Reprod. Biol. Endocrinol. 2012 Feb;10:15.
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Liu J, Kennedy DJ, Yan Y, Shapiro JI. 2012. Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling. Int J Nephrol. 2012 4 21;2012:381320.
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Liu C, Bai Y, Chen Y, Wang Y, Sottejeau Y, Liu L, Li X, Lingrel JB, Malhotra D, Cooper CJ, Shapiro JI, Xie ZJ, Tian J. 2012. Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac dysfunction and myocyte apoptosis. J. Biol. Chem. 2012 May 11;287(20):16390-8.
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Li M, Vanella L, Zhang Y, Shi M, Takaki T, Shapiro JI, Ikehara S. 2012. Stem cell transplantation increases antioxidant effects in diabetic mice. Int. J. Biol. Sci. 2012 Oct;8(10):1335-44.
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Liu J, Yan Y, Liu L, Xie Z, Malhotra D, Joe B, Shapiro JI. 2011. Impairment of Na/K-ATPase signaling in renal proximal tubule contributes to Dahl salt-sensitive hypertension. J. Biol. Chem. 2011 9 10;286(26):22806-13.
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Tian J Drummond C Brewster P He W REn Kaili Xie Y Tuttle K Haller S Jamerson K Dworkin L Cutlip D Murphy T Dagastino R Henrich WL Shapiro JI Cooper CJ. . CIGARETTE SMOKING AND CARDIO-RENAL EVENTS IN PATIENTS WITH ATHEROSCLEROTIC RENAL ARTERY STENOSIS PLOS ONE 2017 In Press

Xie, Z. Shapiro, J.I.. . Na/K-ATPase amplification of oxidant stress; a universal but unrecognized clinical target? Xie, PhD, Zijian and Shapiro, MD, Joseph I. (2016) "Na/K-ATPase amplification of oxidant stress; a universal but unrecognized clinical target?," Marshall Journal of Medicine: Vol. 2: Iss. 2, Article 4.

Hinds, TD, Sodhi, M, Meadows, C, Fedorova, L, Puri, N, Kim, DH, Peterson, S, Shapiro, J, Abraham, NG, Kappas, A. Terry D. Hinds, Jr.*+, Komal Sodhi1*, Charles Meadows1, Larisa Fedorova+, Nitin Puri+, Dong Hyun Kim1, Stephen J. Peterson2 Joseph Shapiro1, Nader G. Abraham1,3 and Attallah Kappas3 . . Increased HO-1 Levels Ameliorate the Development of Fatty Liver Via Reduction of Heme and Recruitment of FGF21

Khitan, Z Raj, DS Malhotra, D Tzmaloukas, AH Shapiro,JI . . Article http://dx.doi.org/10.18590/mjm.2015.vol1.iss1.6

Jacob AD, Shapiro JI. . The Na/K-ATPase as an Amplifier for Oxidant Signals: Brief Historical Review and Possible Implications