Joseph I. Shapiro, MD

Joseph I. Shapiro, MD
Professor
Departments
Clinical Interests
Privileges
Biography
Dr. Shapiro specializes in renal transplant, chronic dialysis, hypertension and diseases of the kidney.
Education & Training
- Medical School: University of Medicine and Dentistry of New Jersey, New Jersey Medical School (Newark, N.J.)
- Residency: Georgetown University (Washington, D.C.)
- Fellowship: University of Colorado - Renal Diseases (Aurora, Colo.)
Honors & Memberships
- 2020 West Virginia Health Care Hall of Fame, WV Executive Magazine
- Albert Nelson Marquis Lifetime Achievement Award, Who's Who
- America's Top Doctor since 2012, Castle Connolly
- Fellow, Society of Magnetic Resonance in Medicine
- Fellow, American Heart Association
- Fellow, American College of Physicians
- Fellow, American Society of Nephrology
- Master , American College of Physicians (ACP)
- Member, International Society of Nephrology
- Member, Colorado Society of Nephrology
- Member, American Association for the Advancement of Science
- Member, Association of Professors of Medicine
- Member, Association of Program Directors in Internal Medicine
- Member, Phi Kappa Phi Honor Society
- Member, American Physiological Society - Cardiovascular Section
- Member, Alpha Omega Alpha Honor Medical Society
- Member, Western Society for Clinical Investigation
- Member, Central Society for Clinical Investigation
- Member, American Society of Nephrology, Hypertension and Kidney Disease
Certification
- Certified: American Board of Internal Medicine, subspecialty certification in Nephrology

Marshall Kidney & Hypertension Center
An outpatient department of Cabell Huntington Hospital
J. Robert Pritchard Dialysis Center
1690 Medical Center Drive
Huntington, WV 25701
Phone: 304-526-2532
Mukherji ST, Brambilla L, Stuart KB, Mayes I, Kutz LC, Chen Y, Barbosa LA, Elmadbouh I, McDermott JP, Haller ST, Romero MF, Soleimani M, Liu J, Shapiro JI, Blanco GV, Xie Z, Pierre SV. 2023. Na/K-ATPase signaling tonically inhibits sodium reabsorption in the renal proximal tubule. FASEB J. 2023 3 4;37(4):e22835.
View on PubMed
Khitan ZJ, Chin KV, Sodhi K, Kheetan M, Alsanani A, Shapiro JI.. 2022. Gut Microbiome and Diet in Populations with Obesity: Role of the Na+/K+-ATPase Transporter Signaling in Severe COVID-19 2022 Jan 19. doi: 10.1002/oby.23387. Online ahead of print.
View on PubMed
Khitan ZJ, Chin KV, Sodhi K, Kheetan M, Alsanani A, Shapiro JI.. 2022. Gut Microbiome and Diet in Populations with Obesity: Role of the Na+/K+-ATPase Transporter Signaling in Severe COVID-19 2022 Jan 19. doi: 10.1002/oby.23387. Online ahead of print.
View on PubMed
Gao Y, Silva LND, Hurley JD, Fan X, Pierre SV, Sodhi K, Liu J, Shapiro JI, Tian J. 2022. Gene module regulation in dilated cardiomyopathy and the role of Na/K-ATPase. PLoS One. 2022 8 2;17(7):e0272117.
View on PubMed
Khitan ZJ, Chin KV, Sodhi K, Kheetan M, Alsanani A, Shapiro JI.. 2022. Gut Microbiome and Diet in Populations with Obesity: Role of the Na+/K+-ATPase Transporter Signaling in Severe COVID-19 .
View on PubMed
Xu Y, Marck P, Huang M, Xie JX, Wang T, Shapiro JI, Cai L, Feng F, Xie Z. 2021. Biased Effect of Cardiotonic Steroids on Na/K-ATPase-Mediated Signal Transduction. Mol Pharmacol. 2021 1 26;99(3):217-225.
View on PubMed
Fan X, Gao Y, Zhang X, Lughmani HY, Kennedy DJ, Haller ST, Pierre SV, Shapiro JI, Tian J. 2021. A strategic expression method of miR-29b and its anti-fibrotic effect based on RNA-sequencing analysis. PLoS One. 2021 3 3;15(12):e0244065.
View on PubMed
Wang J, Wang X, Gao Y, Lin Z, Chen J, Gigantelli J, Shapiro JI, Xie Z, Pierre SV. 2021. Stress Signal Regulation by Na/K-ATPase As a New Approach to Promote Physiological Revascularization in a Mouse Model of Ischemic Retinopathy. Invest Ophthalmol Vis Sci. 2021 5 13;61(14):9.
View on PubMed
Kheetan M, Ogu I, Shapiro JI, Khitan ZJ. 2021. Acute and Chronic Hyponatremia. Front Med (Lausanne). 2021 8 21;8:693738.
View on PubMed
Kutz LC, Cui X, Xie JX, Mukherji ST, Terrell KC, Huang M, Wang X, Wang J, Martin AJ, Pessoa MT, Cai L, Zhu H, Heiny JA, Shapiro JI, Blanco G, Xie Z, Pierre SV. 2021. The Na/K-ATPase a1/Src interaction regulates metabolic reserve and Western diet intolerance. Acta Physiol (Oxf). 2021 3 22;232(3):e13652.
View on PubMed
Liu J, Tian J, Sodhi K, Shapiro JI. 2021. The Na/K-ATPase Signaling and SGLT2 Inhibitor-Mediated Cardiorenal Protection: A Crossed Road? J Membr Biol. 2021 7 24.
View on PubMed
Sergi CM, Udoh UA, Sanabria JD, Rajan PK, Banerjee M, Schade M, Sanabria JA, Smith G, Udoh G, Sodhi K, Pierre S, Shapiro JI, Sanabria JR. 2021. Non-Alcoholic Fatty Liver Disease Progression to Non-Alcoholic Steatohepatitis-Related Primary Liver Cancer 2021 4 28.
View on PubMed
1. Sodhi K; Pratt R.; Wang X.; Lakhani, H.V.; Pillai, S.; Zehra, Z.; Wang, J.; Grover, L; Henderson, Brandon; Denvir, J.; Liu, J.; Abraham, N.G.; Nelson, T.; Shapiro, J.I.. 2021. Role of Adipocyte Na,K-ATPase Oxidant Amplification Loop in Cognitive Decline and Neurodegeneration 103262. Published online 2021 Oct 12. doi: 10.1016/j.isci.2021.103262
. 2020. Adipocyte Specific HO-1 Gene Therapy is Effective in Antioxidant Treatment of Insulin Resistance and Vascular Function in an Obese Mice Model Antioxidants 2020, 9, 40; doi:10.3390/antiox9010040
Shailendra P. Singh Menachem Greenberg Yosef Glick Lars Bellner Gaia Favero Rita Rezzani Luigi Fabrizio Rodella Kevin Agostinucci Joseph I. Shapiro Nader G. Abraham. 2020. Adipocyte Specific HO-1 Gene Therapy is Effective in Antioxidant Treatment of Insulin Resistance and Vascular Function in an Obese Mice Model Antioxidants 2020, 9, 40; doi:10.3390/antiox9010040
Shailendra P. Singh Menachem Greenberg Yosef Glick Lars Bellner Gaia Favero Rita Rezzani Luigi Fabrizio Rodella Kevin Agostinucci Joseph I. Shapiro Nader G. Abraham. 2020. Adipocyte Specific HO-1 Gene Therapy is Effective in Antioxidant Treatment of Insulin Resistance and Vascular Function in an Obese Mice Model Antioxidants 2020, 9, 40; doi:10.3390/antiox9010040
View on PubMed
Liu J, Nie Y, Chaudhry M, Bai F, Chuang J, Sodhi K, Shapiro JI. 2020. The Redox-Sensitive Na/K-ATPase Signaling in Uremic Cardiomyopathy. Int J Mol Sci. 2020 2 20;21(4).
View on PubMed
Wang X, Cai L, Xie JX, Cui X, Zhang J, Wang J, Chen Y, Larre I, Shapiro JI, Pierre SV, Wu D, Zhu GZ, Xie Z. 2020. A caveolin binding motif in Na/K-ATPase is required for stem cell differentiation and organogenesis in mammals and C.elegans. Sci Adv. 2020 6 17;6(22):eaaw5851.
View on PubMed
Alsanani A, Shapiro JI. 2020. Effects of Short-Term Proteinuria on the Incidence of Stroke in Patients With Different Glucose Tolerance Status. J Am Heart Assoc. 2020 6 17;e017288.
View on PubMed
Sodhi K, Wang X, Chaudhry MA, Lakhani HV, Zehra M, Pratt R, Nawab A, Cottrill CL, Snoad B, Bai F, Denvir J, Liu J, Sanabria JR, Xie Z, Abraham NG, Shapiro JI. 2020. Central Role for Adipocyte Na,K-ATPase Oxidant Amplification Loop in the Pathogenesis of Experimental Uremic Cardiomyopathy. J. Am. Soc. Nephrol. 2020 6 27.
View on PubMed
Fakhouri EW, Peterson SJ, Kothari J, Alex R, Shapiro JI, Abraham NG. 2020. Genetic Polymorphisms Complicate COVID-19 Therapy: Pivotal Role of HO-1 in Cytokine Storm. Antioxidants (Basel). 2020 7 28;9(7).
View on PubMed
Sodhi K, Denvir J, Liu J, Sanabria JR, Chen Y, Silverstein R, Xie Z, Abraham NG, Shapiro JI. 2020. Oxidant-Induced Alterations in the Adipocyte Transcriptome: Role of the Na,K-ATPase Oxidant Amplification Loop 2020 Aug 18;21(16):5923.
Gress TW, Mansoor K, Rayyan YM, Khthir RA, Tayyem RF, Tzamaloukas AH, Abraham NG, Shapiro JI, Khitan ZJ. 2020. Relationship between dietary sodium and sugar intake: A cross-sectional study of the National Health and Nutrition Examination Survey 2001-2016. J Clin Hypertens (Greenwich). 2020 8 8.
View on PubMed
Tun S, Spainhower CJ, Cottrill CL, Lakhani HV, Pillai SS, Dilip A, Chaudhry H, Shapiro JI, Sodhi K. 2020. Therapeutic Efficacy of Antioxidants in Ameliorating Obesity Phenotype and Associated Comorbidities. Front Pharmacol. 2020 9 10;11:1234.
View on PubMed
Jiang Liu, Yanling Yan and Joseph I. Shapiro. 2020. The Na/K-ATPase Signaling Regulates Natriuresis in Renal Proximal Tubule Jiang Liu, Yanling Yan and Joseph I. Shapiro (September 30th 2020). The Na/K-ATPase Signaling Regulates Natriuresis in Renal Proximal Tubule [Online First], IntechOpen, DOI: 10.5772/intechopen.92968.
Khitan ZJ, Khawaja I, Mufson MA, Sanabria JR, Abraham NG, Peterson SJ, Sundaram U, Shapiro JI. 2020. Can charcoal improve outcomes in COVID-19 infections? Med Hypotheses. 2020 12 2;144:110176.
View on PubMed
Rajan PK, Udoh UA, Sanabria JD, Banerjee M, Smith G, Schade MS, Sanabria J, Sodhi K, Pierre S, Xie Z, Shapiro JI, Sanabria J. 2020. The Role of Histone Acetylation-/Methylation-Mediated Apoptotic Gene Regulation in Hepatocellular Carcinoma. Int J Mol Sci. 2020 12 2;21(23).
View on PubMed
Xie ZJ, Novograd J, Itzkowitz Y, Sher A, Buchen YD, Sodhi K, Abraham NG, Shapiro JI. 2020. The Pivotal Role of Adipocyte-Na K peptide in Reversing Systemic Inflammation in Obesity and COVID-19 in the Development of Heart Failure. Antioxidants (Basel). 2020 11 19;9(11).
View on PubMed
Maxwell KD, Chuang J, Chaudhry M, Nie Y, Bai F, Sodhi K, Liu J, Shapiro JI. 2020. The potential role of Na-K-ATPase and its signaling in the development of anemia in chronic kidney disease. Am J Physiol Renal Physiol. 2020 12 28;320(2):F234-F242.
View on PubMed
. 2020. Editoral Alsanani A, Shapiro JI. Effects of Short-Term Proteinuria on the Incidence of Stroke in Patients With Different Glucose Tolerance Status. J Am Heart Assoc. 2020 Jul 7;9(13):e017288. doi: 10.1161/JAHA.120.017288. Epub 2020 Jun 13. PMID: 32538236.
View on PubMed
Khitan ZJ, Tzamaloukas AH, Shapiro JI, Gress TW. 2020. Response to: Visaria et al. Everything in moderation: Understanding the interplay between salt and sugar intake. JCH-20-0534. J Clin Hypertens (Greenwich). 2020 10 31.
View on PubMed
Chen T, Brewster P, Tuttle KR, Dworkin LD, Henrich W, Greco BA, Steffes M, Tobe S, Jamerson K, Pencina K, Massaro JM, D'Agostino RB, Cutlip DE, Murphy TP, Cooper CJ, Shapiro JI. 2019. Prediction of cardiovascular outcomes with machine learning techniques: application to the Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL) study. Int J Nephrol Renovasc Dis. 2019 4 10;12:49-58.
View on PubMed
Pratt RD, Brickman C, Nawab A, Cottrill C, Snoad B, Lakhani HV, Jelcick A, Henderson B, Bhardwaj NN, Sanabria JR, Liu J, Xie Z, Abraham NG, Shapiro JI, Sodhi K. 2019. The Adipocyte Na/K-ATPase Oxidant Amplification Loop is the Central Regulator of Western Diet-Induced Obesity and Associated Comorbidities. Sci Rep. 2019 5 30;9(1):7927.
View on PubMed
Cooper CJ, Wehner P, Dailey C, O'Connor N, Kleshinski J, Shapiro JI. 2019. Information within residency monthly evaluation forms at two institutions. Med Educ Online. 2019 6 28;24(1):1635844.
View on PubMed
Lakhani HV, Zehra M, Pillai SS, Puri N, Shapiro JI, Abraham NG, Sodhi K. 2019. Beneficial Role of HO-1-SIRT1 Axis in Attenuating Angiotensin II-Induced Adipocyte Dysfunction. Int J Mol Sci. 2019 7 3;20(13).
View on PubMed
Yan Y, Wang J, Chaudhry MA, Nie Y, Sun S, Carmon J, Shah PT, Bai F, Pratt R, Brickman C, Sodhi K, Kim JH, Pierre S, Malhotra D, Rankin GO, Xie ZJ, Shapiro JI, Liu J. 2019. Metabolic Syndrome and Salt-Sensitive Hypertension in Polygenic Obese TALLYHO/JngJ Mice: Role of Na/K-ATPase Signaling. Int J Mol Sci. 2019 7 19;20(14).
View on PubMed
Singh SP, McClung JA, Thompson E, Glick Y, Greenberg M, Acosta-Baez G, Edris B, Shapiro JI, Abraham NG. 2019. Cardioprotective Heme Oxygenase-1-PGC1a Signaling in Epicardial Fat Attenuates Cardiovascular Risk in Humans as in Obese Mice. Obesity (Silver Spring). 2019 8 24.
View on PubMed
Cooper EL, Xie Y, Nguyen H, Brewster PS, Sholl H, Sharrett M, Ren K, Chen T, Tuttle KR, Haller ST, Jamerson K, Murphy TP, D'Agostino RB, Massaro JM, Henrich W, Cooper CJ, Cutlip DE, Dworkin LD, Shapiro JI. 2019. Early Rapid Decline in Kidney Function in Medically Managed Patients With Atherosclerotic Renal Artery Stenosis. J Am Heart Assoc. 2019 8 23;8(11):e012366.
View on PubMed
Tzamaloukas AH, Khitan ZJ, Glew RH, Roumelioti ME, Rondon-Berrios H, Elisaf MS, Raj DS, Owen J, Sun Y, Siamopoulos KC, Rohrscheib M, Ing TS, Murata GH, Shapiro JI, Malhotra D. 2019. Serum Sodium Concentration and Tonicity in Hyperglycemic Crises: Major Influences and Treatment Implications. J Am Heart Assoc. 2019 9 25;8(19):e011786.
View on PubMed
Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding PJ, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, Malarkannan S, Sodhi K, Shapiro JI, Xie Z, Sahoo D, Silverstein RL. 2019. Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses. Circ. Res. 2019 10 19.
View on PubMed
Peterson S, Thompson E, Liu L, Weingarten J, O’Hanlon K, Bhesania S, Bialczak A, Shapiro J, Abraham N.. 2019. Adipokines and Endothelial Dysfunction: A Potential Biomarker Profile for Cardiovascular Risk in Women with Obesity. 2019Jan,27(1)
Wang X, Shapiro JI. 2019. Evolving concepts in the pathogenesis of uraemic cardiomyopathy. Nat Rev Nephrol. 2019 1 22.
View on PubMed
Lakhani HV, Khanal T, Gabi A, Yousef G, Alam MB, Sharma D, Aljoudi H, Puri N, Thompson E, Shapiro JI, Sodhi K. 2019. Developing a panel of biomarkers and miRNA in patients with myocardial infarction for early intervention strategies of heart failure in West Virginian population. PLoS ONE. 2019 3 21;13(10):e0205329.
View on PubMed
Mansoor K, Kheetan M, Shahnawaz S, Shapiro AP, Patton-Tackett E, Dial L, Rankin G, Santhanam P, Tzamaloukas AH, Nadasdy T, Shapiro JI, Khitan ZJ. 2018. Systematic review of nephrotoxicity of drugs of abuse, 2005-2016. BMC Nephrol. 2018 8 28;18(1):379.
View on PubMed
Bartlett DE, Miller RB, Thiesfeldt S, Lakhani HV, Khanal T, D Pratt R, Cottrill CL, Klug RL, Adkins NS, Bown PC, Nease DB, Shapiro JI, Sodhi K. 2018. Uremic Toxins Activates Na/K-ATPase Oxidant Amplification Loop Causing Phenotypic Changes in Adipocytes in In Vitro Models. Int J Mol Sci. 2018 12 26;19(9).
View on PubMed
Pratt RD, Brickman CR, Cottrill CL, Shapiro JI, Liu J. 2018. The Na/K-ATPase Signaling: From Specific Ligands to General Reactive Oxygen Species. Int J Mol Sci. 2018 9 12;19(9).
View on PubMed
Grigorova YN, Wei W, Petrashevskaya N, Zernetkina V, Juhasz O, Fenner R, Gilbert C, Lakatta EG, Shapiro JI, Bagrov AY, Fedorova OV. 2018. Dietary Sodium Restriction Reduces Arterial Stiffness, Vascular TGF-ß-Dependent Fibrosis and Marinobufagenin in Young Normotensive Rats. Int J Mol Sci. 2018 10 18;19(10).
View on PubMed
Wang W, Shapiro JI. 2018. Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase. Int J Mol Sci. 2018 8 12;19(8).
View on PubMed
Bartlett DE, Miller RB, Thiesfeldt S, Lakhani HV, Shapiro JI, Sodhi K. 2018. The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Aging: Implications in Obesity and Cardiovascular Disease. Int J Mol Sci. 2018 7 26;19(7).
View on PubMed
Gress TW Denvir J Shapiro JI. 2018. Effect of Removing Outliers on Statistical Inference: Implications to Interpretation of Experimental Data in Medical Research Vol. 4: Iss. 2, Article 9. DOI: http://dx.doi.org/10.18590/mjm.2018.vol4.iss2.9
Roumelioti M Glew RH Khitan ZJ Rondon-Berrios H Argyropoulos CP Malhotra D Raj DJ Agaba EI Rohrscheib M Murata GH Shapiro JI Tzamaloukas AH. 2018. Fluid balance concepts in medicine: Principles and practice World J Nephrol 7(1):1-28. 2018.
Khitan ZJ, Tzamaloukas AH, Brodsky S, Shapiro JI. 2018. Dihydropyridine calcium channel blockers in the elderly with diabetic nephropathy: Are they safe? J Clin Hypertens (Greenwich). 2018 1 10.
View on PubMed
Liu J, Lilly MN, Shapiro JI. 2018. Targeting Na/K-ATPase Signaling: A New Approach to Control Oxidative Stress. Curr. Pharm. Des. 2018 1 11.
View on PubMed
Khitan ZJ, Shweihat YR, Tzamaloukas AH, Shapiro JI. 2018. Dietary potassium and cardiovascular profile. Results from the modification of diet in renal disease dataset. J Clin Hypertens (Greenwich). 2018 2 20.
View on PubMed
Ogu I, Shweihat YR, Shapiro JI, Khitan ZJ. 2018. Stroke volume and proteinuria in obesity-related glomerulopathy: potential role in pathogenesis and choice of antihypertensive regimen. J Clin Hypertens (Greenwich). 2018 2 16.
View on PubMed
Roumelioti ME, Ing TS, Rondon-Berrios H, Glew RH, Khitan ZJ, Sun Y, Malhotra D, Raj DS, Agaba EI, Murata GH, Shapiro JI, Tzamaloukas AH. 2018. Principles of quantitative water and electrolyte replacement of losses from osmotic diuresis. Int Urol Nephrol. 2018 3 8.
View on PubMed
Khitan ZJ, Kheetan MM, Shapiro JI. 2018. PURE is not so pure when it comes to dietary sodium and cardiovascular events! J Clin Hypertens (Greenwich). 2018 4 1;20(5):976-977.
View on PubMed
Sodhi K, Nichols A, Mallick A, Klug RL, Liu J, Wang X, Srikanthan K, Goguet-Rubio P, Nawab A, Pratt R, Lilly MN, Sanabria JR, Xie Z, Abraham NG, Shapiro JI. 2018. The Na/K-ATPase Oxidant Amplification Loop Regulates Aging. Sci Rep. 2018 6 28;8(1):9721.
View on PubMed
Peterson SJ, Shapiro JI, Thompson E, Singh S, Liu L, Weingarten JA, O'Hanlon K, Bialczak A, Bhesania SR, Abraham NG. 2018. Oxidized HDL, Adipokines, and Endothelial Dysfunction: A Potential Biomarker Profile for Cardiovascular Risk in Women with Obesity. Obesity (Silver Spring). 2018 12 21;27(1):87-93.
View on PubMed
Lakhani HV, Sharma D, Dodrill MW, Nawab A, Sharma N, Cottrill CL, Shapiro JI, Sodhi K. 2018. Phenotypic Alteration of Hepatocytes in Non-Alcoholic Fatty Liver Disease. Int J Med Sci. 2018 12 28;15(14):1591-1599.
View on PubMed
Sodhi K Srikanthan K Goguet-Rubio P Nichols A Mallick A Nawab A Martin R Shah PT Chaudhry M Sigdel S El-Hamdani M Liu J Xie Z Abraham NG Shapiro JI. 2017. pNaKtide Attenuates Steatohepatitis and Atherosclerosis by Blocking Na/K-ATPase/ROS Amplification in C57Bl6 and ApoE Knockout Mice Fed a Western Diet SCI REP-UK 2017 Mar 15;7(1):193
View on PubMed
Santhanam P, Shapiro JI, Khitan Z. 2017. Association between dietary potassium, body mass index, and proteinuria in normotensive and hypertensive individuals: Results from the Modification of Diet in Renal Disease study baseline data. J Clin Hypertens (Greenwich). 2017 4 4;19(5):558-559.
View on PubMed
Drummond CA, Brewster PS, He W, Ren K, Xie Y, Tuttle KR, Haller ST, Jamerson K, Dworkin LD, Cutlip DE, Murphy TP, D'Agostino RB Sr, Henrich WL, Tian J, Shapiro JI, Cooper CJ.. 2017. Cigarette smoking and cardio-renal events in patients with atherosclerotic renal artery stenosis. PLoS ONE. PLoS One. 2017 Mar 17;12(3):e0173562. doi: 10.1371/journal.pone.0173562.
View on PubMed
Goguet-Rubio, P, Klug, R.L., Lakhani, V.H, Nichols, A, Dana L. Sharma, D.L., Srikanthan, K., Puri, N. O’Hanlon, K.M.,Shapiro JI. 2017. Existence of a Strong Correlation of Biomarkers and miRNA in Females with Metabolic Syndrome and Obesity in a Population of West Virginia. Int J Med Sci. 2017 Mar
View on PubMed
Wang X, Liu J, Drummond, CA, and Shapiro JI. 2017. Sodium potassium adenosine triphosphatase (Na/K-ATPase) as a therapeutic target for uremic cardiomyopathy EXPERT OPIN THER TAR Expert Opinion on Therapeutic Targets. 2017 May; 21(5):531-541
View on PubMed
Alaini A, Malhotra D, Rondon-Berrios H, Argyropoulos CP, Khitan ZJ, Raj DSC, Rohrscheib M, Shapiro JI, Tzamaloukas AH. 2017. Establishing the presence or absence of chronic kidney disease: uses and limiations of formualas estimating the glomerular filtration rate World J Methodol 2017 7:73-92
Sharma DL, Lakhani HV, Klug RL, Snoad B, El-Hamdani R, Shapiro JI, Sodhi K. 2017. Investigating Molecular Connections of Non-alcoholic Fatty Liver Disease with Associated Pathological Conditions in West Virginia for Biomarker Analysis. J Clin Cell Immunol. 2017 11 28;8(5).
View on PubMed
Xie JX Zhang S Cui X Zhang J Yu H Khalaf FK Malhotra D Kennedy DJ Shapiro JI Tian J Haller ST. 2017. Na/K-ATPase/src complex mediates regulation of CD40 in renal parenchyma Nephrology Dialysis Transplantation, 2017 , gfx334, https://doi.org/10.1093/ndt/gfx334
View on PubMed
Wang X, Chaudhry MA, Nie Y, Xie Z, Shapiro JI, Liu J. 2017. A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy. J Vis Exp. 2017 11 21;(129).
View on PubMed
Ogu I, Surindran S, Shapiro JI. 2017. Hyponatremia in Hypothyroid Disorders: Current Understanding. • Ogu I, Surindran S, Shapiro JI (2017) Hyponatremia in Hypothyroid Disorders: Current Understanding. JSM Thyroid Disord Manag 2(2):1014.
Cao J, Singh SP, McClung JA, Joseph G, Vanella L, Barbagallo I, Jiang H, Falck JR, Arad M, Shapiro JI, Abraham NG. 2017. EET intervention on Wnt1, NOV, and HO-1 signaling prevents obesity-induced cardiomyopathy in obese mice. Am. J. Physiol. Heart Circ. Physiol. 2017 6 4;313(2):H368-H380.
View on PubMed
Khitan ZJ, Shapiro JI. 2017. The Association between HDL-C and Hyponatremia. is There Something Else Low? Am. J. Med. 2017 7 22.
View on PubMed
Loudin S, Werthammer J, Prunty L, Murray S, Shapiro JI, Davies TH. 2017. A management strategy that reduces NICU admissions and decreases charges from the front line of the neonatal abstinence syndrome epidemic. J Perinatol. 2017 7 7.
View on PubMed
Liu J, Yan Y, Nie Y, Shapiro JI.. 2017. Na/K-ATPase Signaling and Salt Sensitivity: The Role of Oxidative Stress. Antioxidants (Basel). Antioxidants.2017, 6(1), 18;
View on PubMed
Nawab A, Nichols A, Klug R, Shapiro JI, Sodhi K. 2017. Spin Trapping: A Review for the Study of Obesity Related Oxidative Stress and Na(+)/K(+)-ATPase. J Clin Cell Immunol. 2017 8 18;8(3).
View on PubMed
KhitanZ , Shapiro A, Shah PT, Sanabria JR, Santhanam P, Sodhi, Abraham NG, Shapiro JI. 2017. Predicting Adverse Outcomes in Chronic Kidney Disease Using Machine Learning Methods: Data from the Modification of Diet in Renal Disease Marshall Journal of Medicine: Vol. 3: Iss. 4, Article 10.
Rondon-Berrios H Argyropoulos C Ing TS Raj DS Malhotra D Agaba EI Rohrscheib M Khitan ZJ Murata GH Shapiro JI Tzamaloukas AH. . 2017. Hypertonicity: Clinical entities, manifestations and treatment. World J Nephrol. World J Nephrol. 2017 Jan 6;6(1):1-13.
View on PubMed
Shapiro JI. 2017. Education of Nurse Practitioners and Physician Assistants; What Role, if any, for Physicians in Determining Their Scope of Practice? Marshall Journal of Medicine: Vol. 3: Iss. 1, Article 3.
Sodhi K, Hilgefort J, Banks G, Gilliam C, Stevens S, Ansinelli HA, Getty M, Abraham NG, Shapiro JI, Khitan Z. 2016. Uric Acid-Induced Adipocyte Dysfunction Is Attenuated by HO-1 Upregulation: Potential Role of Antioxidant Therapy to Target Obesity. Stem Cells Int. 2016 Nov;2016:8197325.
View on PubMed
Sodhi K, Puri N, Favero G, Stevens S, Meadows C, Abraham NG, Rezzani R, Ansinelli H, Lebovics E, Shapiro JI. 2016. Fructose Mediated Non-Alcoholic Fatty Liver Is Attenuated by HO-1-SIRT1 Module in Murine Hepatocytes and Mice Fed a High Fructose Diet. PLoS ONE. 2016 5 5;10(6):e0128648.
View on PubMed
Shah PT, Martin R, Sanabria J, Khitan Z, Santhanam P, Sodhi K, Abraham NG and Shapiro JI. 2016. Adiposity Predicts Pulse Pressure in Subjects with Chronic Kidney Disease: Data from the Modification of Diet in Renal Disease J Cardiol Curr Res 2016, 7(2): 00240
Argyropoulos C, Rondon-Berrios H, Raj DS, Malhotra D, Agaba EI, Rohrscheib M, Khitan Z, Murata GH, Shapiro JI, Tzamaloukas AH. 2016. Hypertonicity: Pathophysiologic Concept and Experimental Studies. Cureus. 2016 May;8(5):e596.
View on PubMed
Feyh A, Bracero L, Lakhani HV, Santhanam P, Shapiro JI, Khitan Z, Sodhi K. 2016. Role of Dietary Components in Modulating Hypertension. J Clin Exp Cardiolog. 2016 Apr;7(4).
View on PubMed
Yan Y, Shapiro JI. 2016. The physiological and clinical importance of sodium potassium ATPase in cardiovascular diseases. Curr Opin Pharmacol. 2016 12 15;27:43-9.
View on PubMed
Shah PT, Martin R, Yan Y, Shapiro JI, Liu J. 2016. Carbonylation Modification Regulates Na/K-ATPase Signaling and Salt Sensitivity: A Review and a Hypothesis. Front Physiol. 2016 Jun;7:256.
View on PubMed
Shaver A, Nichols A, Thompson E, Mallick A, Payne K, Jones C, Manne ND, Sundaram S, Shapiro JI, Sodhi K. 2016. Role of Serum Biomarkers in Early Detection of Diabetic Cardiomyopathy in the West Virginian Population. Int J Med Sci. 2016 Feb;13(3):161-8.
View on PubMed
Peterson SJ, Vanella L, Gotlinger K, Jiang H, Singh SP, Sodhi K, Maher E, O'Hanlon K, Shapiro JI, Abraham NG. 2016. Oxidized HDL is a potent inducer of adipogenesis and causes activation of the Ang-II and 20-HETE systems in human obese females. Prostaglandins Other Lipid Mediat. 2016 May 11;123:68-77.
View on PubMed
Peterson SJ Vanella L Bialczak A Schragenheim J Li M Beliner L Shapiro JI Abraham NG. 2016. Oxidized HDL and isoprostane exert a potent adipogenic effect on stem cells: Where in the lineage? Cell, Stem Cells and Regenerative Medicine 2(1):doi Htt;://dx.doi.org/10.16966/csrm.109
Tuttle KR, Dworkin LD, Henrich W, Greco BA, Steffes M, Tobe S, Shapiro JI, Jamerson K, Lyass A, Pencina K, Massaro JM, D'Agostino RB, Cutlip DE, Murphy TP, Cooper CJ. 2016. Effects of Stenting for Atherosclerotic Renal Artery Stenosis on eGFR and Predictors of Clinical Events in the CORAL Trial. Clin J Am Soc Nephrol. 2016 Jul 7;11(7):1180-8.
View on PubMed
Haller ST, Kumarasamy S, Folt DA, Wuecher LM, Stepkowski S, Karamchandani M, Waghulde H, Mell B, Chaudhry M, Lessar K, Upadhyaya S, Drummond CA, Tian J, Filpiak WE, SAunders TL, Shapiro JI, Joe B, Cooper CJ. 2016. Targeted disruption of Cd40 in a genetically hypertensive rat model attenuates renal fibrosis and proteinuria, independent of blood pressure. Kidney Int. Kidney International 2016 Sep 28. pii: S0085-2538(16)30443-4. doi: 10.1016/j.kint.2016.08.015.
View on PubMed
Yan Y, Shapiro AP, Mopidevi BR, Chaudhry MA, Maxwell K, Haller ST, Drummond CA, Kennedy DJ, Tian J, Malhotra D, Xie ZJ, Shapiro JI, Liu J. 2016. Protein Carbonylation of an Amino Acid Residue of the Na/K-ATPase a1 Subunit Determines Na/K-ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells. J Am Heart Assoc. JAHA 2016 Sep;5(9).
View on PubMed
Srikanthan K, Shapiro JI, Sodhi K. 2016. The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease. Molecules. 2016 Sep;21(9).
View on PubMed
Drummond CA, Hill MC, Shi H, Fan X, Xie JX, Haller ST, Kennedy DJ, Liu J, Garrett MR, Xie Z, Cooper CJ, Shapiro JI, Tian J.. 2016. Na/K-ATPase signaling regulates collagen synthesis through microRNA-29b-3p in cardiac fibroblasts. Physiol. Genomics. Physiol Genomics. 2016 Mar;48(3):220-9. doi: 10.1152/physiolgenomics.00116.2015
View on PubMed
Drummond CA, Crotty Alexander LE, Haller ST, Fan X, Xie JX, Kennedy DJ, Liu J, Yan Y, Hernandez DA, Mathew DP, Cooper CJ, Shapiro JI, Tian J.. 2016. Cigarette smoking causes epigenetic changes associated with cardiorenal fibrosis. Physiol. Genomics. .Physiol Genomics. 2016 Dec 1;48(12):950-960.
View on PubMed
Haller ST, Yan Y, Drummond CA, Xie J, Tian J, Kennedy DJ, Shilova VY, Xie Z, Liu J, Cooper CJ, Malhotra D, Shapiro JI, Fedorova OV, Bagrov AY.. 2016. Rapamycin Attenuates Cardiac Fibrosis in Experimental Uremic Cardiomyopathy by Reducing Marinobufagenin Levels and Inhibiting Downstream Pro-Fibrotic Signaling. J AM HEART ASSOC J Am Heart Assoc. 2016 Sep 30;5(10). pii: e004106.
View on PubMed
Liu J, Tian J, Chaudhry M, Maxwell K, Yan Y, Wang X, Shah PT, Khawaja AA, Martin R, Robinette TJ, El-Hamdani A, Dodrill MW, Sodhi K, Drummond CA, Haller ST, Kennedy DJ, Abraham NG, Xie Z, Shapiro JI.. 2016. Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates Experimental Uremic Cardiomyopathy. Sci Rep. Sci Rep. 2016 Oct 4;6:34592. doi: 10.1038/srep34592
View on PubMed
Sodhi K, Bracero L, Feyh A, Nichols A, Srikanthan K, Latif T, Preston D, Shapiro JI, Elitsur Y.. 2016. Role of Serum Biomarkers in Early Detection of Non-Alcoholic Steatohepatitis and Fibrosis in West Virginian Children. J Clin Cell Immunol. J Clin Cell Immunol. 2016 Feb;7(1). pii: 393
View on PubMed
Murphy TP, Cooper CJ, Pencina KM, D'Agostino R, Massaro J, Cutlip DE, Jamerson K, Matsumoto AH, Henrich W, Shapiro JI, Tuttle KR, Cohen DJ, Steffes M, Gao Q, Metzger DC, Abernethy WB, Textor SC, Briguglio J, Hirsch AT, Tobe S, Dworkin LD. 2016. Relationship of Albuminuria and Renal Artery Stent Outcomes: Results From the CORAL Randomized Clinical Trial (Cardiovascular Outcomes With Renal Artery Lesions). Hypertension. 2016 Sep 19.
View on PubMed
Preeya T. Shah, Anna P. Shapiro, Zeid Khitan, Prasanna Santhanam, Joseph I. Shapiro. 2016. Why Does Obesity Lead to Hypertension? Further Lessons from the Intersalt Study. Shah, Preeya T.; Shapiro, Anna P.; Khitan, Zeid MD; Santhanam, Prasanna MD; and Shapiro, Joseph I. MD (2016) "Why Does Obesity Lead to Hypertension? Further Lessons from the Intersalt Study.," Marshall Journal of Medicine: Vol. 2: Iss. 1, Article 7
Srikanthan K, Feyh A, Visweshwar H, Shapiro JI, Sodhi K. 2016. Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population. Int J Med Sci. 2016 10 22;13(1):25-38.
View on PubMed
Yu S, Brewster P, Ren K, He W, Xiang K, Tuttle K, Jamerson K, Dworkin L, Cutlip D, Solomon S, Murphy T, Dagostino R, Henrich W, Shapiro J, Cooper C. 2015. STENTING OF ATHEROSCLEROTIC RENAL ARTERY STENOSIS DOES NOT IMPROVE CLINICAL OUTCOMES IN PATIENTS PRESENTING WITH CONGESTIVE HEART FAILURE, AN ANALYSIS OF THE CORAL TRIAL. J. Hypertens. 2015 Jun;33 Suppl 1:e49.
View on PubMed
Gullo, CG, McCarthy MJ, Shapiro JI, and Miller, B. 2015. Predicting Medical Student Success on Licensure Exams Predicting Medical Student Success on Licensure Exams. Gullo CG, McCarthy MJ, Shapiro, JI, and Miller B. Med Science Educator; 07 Oct. 2015; first online pp1-7.
Sodhi K, Maxwell K, Yan Y, Liu J, Chaudhry MA, Getty M, Xie Z, Abraham NG, Shapiro JI. 2015. pNaKtide inhibits Na/K-ATPase reactive oxygen species amplification and attenuates adipogenesis. Sci Adv. 2015 11 26;1(9):e1500781.
View on PubMed
Murphy TP, Cooper CJ, Matsumoto AH, Cutlip DE, Pencina KM, Jamerson K, Tuttle KR, Shapiro JI, D'Agostino R, Massaro J, Henrich W, Dworkin LD. 2015. Renal Artery Stent Outcomes: Effect of Baseline Blood Pressure, Stenosis Severity, and Translesion Pressure Gradient. J. Am. Coll. Cardiol. 2015 Dec 8;66(22):2487-94.
View on PubMed
Cao J, Tsenovoy PL, Thompson EA, Falck JR, Touchon R, Sodhi K, Rezzani R, Shapiro JI, Abraham NG. 2015. Agonists of epoxyeicosatrienoic acids reduce infarct size and ameliorate cardiac dysfunction via activation of HO-1 and Wnt1 canonical pathway. Prostaglandins Other Lipid Mediat. 2015 Feb 9.
View on PubMed
Sodhi K, Pesce P, Stevens S, Puri N, Getty M, Hutcheson R, Sacerdoti D, and Shapiro J.. 2015. Impairment of Heme Oxygenase Expression in Immuno-suppressed Mice Exacerbates Ischemic Heart Myocytes Cell Death: Reversible by Bilirubin and Restoration of Nitric Oxide Journal of Cardiology and Therapy 2015; 2(2): 291-301
Kyle Maxwell, Preeya Shah and Joseph I. Shapiro. 2015. The plasmalemmal Na/K-ATPase: an amplifier for reactive oxygen species? J Hypertension 4:100197 doi:10.4172/2167-1095,1000197.
Zeid Khitan MD, Deepak Malhotra MD PhD, Dominic S Raj MD, Antonios H. Tzamaloukas MD, and Joseph I Shapiro MD. 2015. Alkali Therapy in Lactic Acidosis Khitan,, Zeid J. MD; Malhotra,, Deepak MD; Raj,, Dominic S. MD; Tzamaloukas,, Antonios H. MD; and Shapiro,, Joseph I. MD (2015) "Alkali Therapy in Lactic Acidosis,"Marshall Journal of Medicine: Vol. 1: Iss. 1, Article 6.
Shah P, Maxwell K, Shapiro JI. 2015. Dashing away hypertension World J Hypertens. 4:119-128, 2015
Wehner P, Shapiro JI. 2014. Renal denervation to treat cardiac fibrosis? J Am Heart Assoc. 2014 Dec;3(6).
View on PubMed
Drummond CA, Buddny G, Haller ST, Liu J, Yan Y, Xie Z, Malhotra D, Shapiro JI, Tian J. 2014. Gender differences in the development of uremic cardiomyopathy following partial nephrectomy: Role of progesterone. J Hypertens (Los Angel). 2014 1 10;2.
View on PubMed
Hinds TD, Sodhi K, Meadows C, Fedorova L, Puri N, Kim DH, Peterson SJ, Shapiro J, Abraham NG, Kappas A. 2014. Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21. Obesity (Silver Spring). 2014 11 5;22(3):705-12.
View on PubMed
Sodhi K, Puri N, Kim DH, Hinds TD, Stechschulte LA, Favero G, Rodella L, Shapiro JI, Jude D, Abraham NG. 2014. PPARd binding to heme oxygenase 1 promoter prevents angiotensin II-induced adipocyte dysfunction in Goldblatt hypertensive rats. Int J Obes (Lond). 2014 12 15;38(3):456-65.
View on PubMed
Yan Y, Shapiro AP, Haller S, Katragadda V, Liu L, Tian J, Basrur V, Malhotra D, Xie ZJ, Abraham NG, Shapiro JI, Liu J. 2014. Involvement of reactive oxygen species in a feed-forward mechanism of Na/K-ATPase-mediated signaling transduction. J. Biol. Chem. 2014 2 5;288(47):34249-58.
View on PubMed
Drummond CA, Sayed M, Evans KL, Shi H, Wang X, Haller ST, Liu J, Cooper CJ, Xie Z, Shapiro JI, Tian J. 2014. Reduction of Na/K-ATPase affects cardiac remodeling and increases c-kit cell abundance in partial nephrectomized mice. Am. J. Physiol. Heart Circ. Physiol. 2014 Jun 15;306(12):H1631-43.
View on PubMed
Haller ST, Drummond CA, Yan Y, Liu J, Tian J, Malhotra D, Shapiro JI. 2014. Passive immunization against marinobufagenin attenuates renal fibrosis and improves renal function in experimental renal disease. Am. J. Hypertens. 2014 12 15;27(4):603-9.
View on PubMed
Cooper CJ, Murphy TP, Cutlip DE, Jamerson K, Henrich W, Reid DM, Cohen DJ, Matsumoto AH, Steffes M, Jaff MR, Prince MR, Lewis EF, Tuttle KR, Shapiro JI, Rundback JH, Massaro JM, D'Agostino RB, Dworkin LD, CORAL Investigators. 2014. Stenting and medical therapy for atherosclerotic renal-artery stenosis. N. Engl. J. Med. 2014 Jan 2;370(1):13-22.
View on PubMed
Sun Y, Mills D, Ing TS, Shapiro JI, Tzamaloukas AH. 2014. Body sodium, potassium and water in peritoneal dialysis-associated hyponatremia. Perit Dial Int. 2014 May;34(3):253-9.
View on PubMed
Xie JX, Shapiro AP, Shapiro JI. 2014. The Trade-Off between Dietary Salt and Cardiovascular Disease; A Role for Na/K-ATPase Signaling? Front Endocrinol (Lausanne). 2014 Jul;5:97.
View on PubMed
Miller B, Dzwonek B, McGuffin A, Shapiro JI. 2014. From LCME probation to compliance: the Marshall University Joan C Edwards School of Medicine experience. Adv Med Educ Pract. 2014 Oct;5:377-82.
View on PubMed
Khitan Z, Harsh M, Sodhi K, Shapiro JI, Abraham NG. 2014. HO-1 Upregulation Attenuates Adipocyte Dysfunction, Obesity, and Isoprostane Levels in Mice Fed High Fructose Diets. J Nutr Metab. 2014 Sep;2014:980547.
View on PubMed
Dial L, Liu J, Shapiro JI. 2014. Cardiotonic steroids in adaptation to dietary salt intake. Curr Clin Pharmacol. 2014;9(3):298-309.
View on PubMed
Tzamaloukas AH, Shapiro JI, Raj DS, Murata GH, Glew RH, Malhotra D. 2014. Management of Severe Hyponatremia: Infusion of Hypertonic Saline and Desmopressin or Infusion of Vasopressin Inhibitors? Am. J. Med. Sci. 2014 Sep 22.
View on PubMed
Tzamaloukas AH, Malhotra D, Rosen BH, Raj DS, Murata GH, Shapiro JI. 2013. Principles of management of severe hyponatremia. J Am Heart Assoc. 2013 Feb;2(1):e005199.
View on PubMed
Haller ST, Kalra PA, Ritchie JP, Chrysochou T, Brewster P, He W, Yu H, Shapiro JI, Cooper CJ. 2013. Effect of CD40 and sCD40L on renal function and survival in patients with renal artery stenosis. Hypertension. 2013 Apr;61(4):894-900.
View on PubMed
Dial L, Liu J, Shapiro JI. 2013. The tradeoff between natriuresis and cardiac and renal fibrosis. Curr Clin Pharmacol. J Hypertension 2013 5: 1-16.
View on PubMed
Kim DH, Puri N, Sodhi K, Falck JR, Abraham NG, Shapiro J, Schwartzman ML. 2013. Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes. J. Lipid Res. 2013 Mar;54(3):786-93.
View on PubMed
Kennedy DJ, Chen Y, Huang W, Viterna J, Liu J, Westfall K, Tian J, Bartlett DJ, Tang WH, Xie Z, Shapiro JI, Silverstein RL. 2013. CD36 and Na/K-ATPase-a1 Form a Proinflammatory Signaling Loop in Kidney. Hypertension. 2013 Jan;61(1):216-24.
View on PubMed
Ahmed S, Shapiro JI. 2013. Obstructive Sleep Apnea and Hypertension 2013 Jul 6;
Murphy TP, Cooper CJ, Cutlip DE, Matsumoto A, Jamerson K, Rundback J, Rosenfield KA, Henrich W, Shapiro J, Massaro J, Yen CH, Burtch H, Thum C, Reid D, Dworkin L. 2013. Roll-in Experience from the Cardiovascular Outcomes with Renal Atherosclerotic Lesions (CORAL) Study. J Vasc Interv Radiol. 2013 Dec 7.
View on PubMed
Fedorova LV, Tamirisa A, Kennedy DJ, Haller ST, Budnyy G, Shapiro JI, Malhotra D. 2013. Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach. BMC Nephrol. 2013 Oct 4;14(1):209.
View on PubMed
Vanella L, Sodhi K, Kim DH, Puri N, Maheshwari M, Hinds TD, Bellner L, Goldstein D, Peterson SJ, Shapiro JI, Abraham NG. 2013. Increased heme-oxygenase 1 expression decreases adipocyte differentiation and lipid accumulation in mesenchymal stem cells via upregulation of the canonical Wnt signaling cascade. Stem Cell Res Ther. 2013 Mar 12;4(2):28.
View on PubMed
Tzamaloukas, AH, Y Sun, NK Konstantinov, TS Ing, RI Dorin, D Malhotra, GH Murata and JI Shapiro. 2013. Principles of quantitative fluid and cation replacement in extreme hyperglycemia. Cureus
Shapiro J. 2013. Simple acid-base disorders - Metabolic Acidosis book chapter
Fedorova LV, Sodhi K, Gatto-Weis C, Puri N, Hinds TD, Shapiro JI, Malhotra D. 2013. Peroxisome proliferator-activated receptor d agonist, HPP593, prevents renal necrosis under chronic ischemia. PLoS ONE. 2013 May;8(5):e64436.
View on PubMed
Fedorova L, Gatto-Weis C, Smaili S, Khurshid N, Shapiro JI, Malhotra D, Horrigan T. 2012. Down-regulation of the transcription factor snail in the placentas of patients with preeclampsia and in a rat model of preeclampsia. Reprod. Biol. Endocrinol. 2012 Feb;10:15.
View on PubMed
Shapiro JI, Dial LD. 2012. How safe is unilateral nephrectomy? Hypertension. 2012 Dec;60(6):1383-4.
View on PubMed
Joe B, Shapiro JI. 2012. Molecular mechanisms of experimental salt-sensitive hypertension. J Am Heart Assoc. 2012 Jun;1(3):e002121.
View on PubMed
Haller ST, Kennedy DJ, Shidyak A, Budny GV, Malhotra D, Fedorova OV, Shapiro JI, Bagrov AY. 2012. Monoclonal antibody against marinobufagenin reverses cardiac fibrosis in rats with chronic renal failure. Am. J. Hypertens. 2012 Jun;25(6):690-6.
View on PubMed
Gupta S, Yan Y, Malhotra D, Liu J, Xie Z, Najjar SM, Shapiro JI. 2012. Ouabain and insulin induce sodium pump endocytosis in renal epithelium. Hypertension. 2012 4 18;59(3):665-72.
View on PubMed
Yan Y, Haller S, Shapiro A, Malhotra N, Tian J, Xie Z, Malhotra D, Shapiro JI, Liu J. 2012. Ouabain-stimulated trafficking regulation of the Na/K-ATPase and NHE3 in renal proximal tubule cells. Mol. Cell. Biochem. 2012 10 16;367(1-2):175-83.
View on PubMed
Liu J, Kennedy DJ, Yan Y, Shapiro JI. 2012. Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling. Int J Nephrol. 2012 4 21;2012:381320.
View on PubMed
Liu C, Bai Y, Chen Y, Wang Y, Sottejeau Y, Liu L, Li X, Lingrel JB, Malhotra D, Cooper CJ, Shapiro JI, Xie ZJ, Tian J. 2012. Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac dysfunction and myocyte apoptosis. J. Biol. Chem. 2012 May 11;287(20):16390-8.
View on PubMed
Li M, Vanella L, Zhang Y, Shi M, Takaki T, Shapiro JI, Ikehara S. 2012. Stem cell transplantation increases antioxidant effects in diabetic mice. Int. J. Biol. Sci. 2012 Oct;8(10):1335-44.
View on PubMed
Liu J, Yan Y, Liu L, Xie Z, Malhotra D, Joe B, Shapiro JI. 2011. Impairment of Na/K-ATPase signaling in renal proximal tubule contributes to Dahl salt-sensitive hypertension. J. Biol. Chem. 2011 9 10;286(26):22806-13.
View on PubMed
Xie, Z. Shapiro, J.I.. . Na/K-ATPase amplification of oxidant stress; a universal but unrecognized clinical target? Xie, PhD, Zijian and Shapiro, MD, Joseph I. (2016) "Na/K-ATPase amplification of oxidant stress; a universal but unrecognized clinical target?," Marshall Journal of Medicine: Vol. 2: Iss. 2, Article 4.
Hinds, TD, Sodhi, M, Meadows, C, Fedorova, L, Puri, N, Kim, DH, Peterson, S, Shapiro, J, Abraham, NG, Kappas, A. Terry D. Hinds, Jr.*+, Komal Sodhi1*, Charles Meadows1, Larisa Fedorova+, Nitin Puri+, Dong Hyun Kim1, Stephen J. Peterson2 Joseph Shapiro1, Nader G. Abraham1,3 and Attallah Kappas3 . . Increased HO-1 Levels Ameliorate the Development of Fatty Liver Via Reduction of Heme and Recruitment of FGF21
Khitan, Z Raj, DS Malhotra, D Tzmaloukas, AH Shapiro,JI . . Article http://dx.doi.org/10.18590/mjm.2015.vol1.iss1.6
Jacob AD, Shapiro JI. . The Na/K-ATPase as an Amplifier for Oxidant Signals: Brief Historical Review and Possible Implications