Maria T. Tirona, MD

Chief, Hematology/Oncology; Chief, Medical Oncology


Clinical Interests

  • Oncology - Medical


Education & Training

  • Medical School: University of the East Ramon Magsaysay Memorial Medical Center (Quezon City, Philippines)
  • Residency: Mercy Hospital of Buffalo (Buffalo, N.Y.)
  • Fellowship: Emory University Hospital - Hematology/Oncology (Atlanta, Ga.)

Honors & Memberships

  • America's Top Doctor since 2019, Castle Connolly
  • Fellow, American College of Physicians and Surgeons
  • Member, National Cancer Institute of Canada Clinical Trials Group
  • Member, College of Physicians and Surgeons of Saskachewan
  • Member, Canadian Medical Protective Association
  • Member, American Society of Clinical Oncology
  • Member, Canadian National Committee on Colorectal Cancer Screening
  • Member, Canadian and Saskatchewan Medical Associations
  • Member, Medical Group Management Association
  • Member, West Virginia Oncology Society
  • Member, West Virginia Clinical Trials Working


  • Certified: American Board of Internal Medicine, subspecialty certification in Medical Oncology

Edwards Comprehensive Cancer Center

An outpatient department of Cabell Huntington Hospital
1400 Hal Greer Blvd.
Huntington, WV 25701
Phone: 304.399.6500

Map & Directions

Brown K, Modi K, Light R, Cox A, Long T, Gadepalli RS, Rimoldi J, Miles S, Rankin G, Valentovic M, Denning K, Tirona M, Finch P, Hess J, Dasgupta P. 2023. Anti-cancer Activity of Region B capsaicin analogs 2023 March 31, 66 (7): 4294-4323.

Merritt JC, Richbart SD, Moles EG, Cox AJ, Brown KC, Miles SL, Finch PT, Hess JA, Tirona MT, Valentovic MA, Dasgupta P. 2022. Anti-cancer activity of sustained release capsaicin formulations. Pharmacol Ther. 2022 3 30;238:108177.
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Richbart SD, Merritt JC, Moles EG, Brown KC, Adeluola AA, Finch PT, Hess JA, Tirona MT, Miles SL, Valentovic MA, Dasgupta AP. 2022. Spherical Invasion Assay: A Novel Method to Measure Invasion of Cancer Cells. Bio Protoc. 2022 3 29;12(4):e4320.
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Dasgupta P, Richbart S, Friedman J, Brown K, Gadapalli R, Miles S, Rimoldi J, Rankin GO, Valentovic M, Tirona, M. 2021. Non-pungent N-AVAM capsaicin analogs and cancer therapy 2021 Feb 11;64(3):1346-1361
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Lakhani HV, Pillai SS, Zehra M, Dao B, Tirona MT, Thompson E, Sodhi K. 2021. Detecting early onset of anthracyclines-induced cardiotoxicity using a novel panel of biomarkers in West-Virginian population with breast cancer. Sci Rep. 2021 11 5;11(1):7954.
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Richbart SD, Friedman JR, Brown KC, Gadepalli RS, Miles SL, Rimoldi JM, Rankin GO, Valentovic MA, Tirona MT, Finch PT, Hess JA, Dasgupta P. 2021. Nonpungent N-AVAM Capsaicin Analogues and Cancer Therapy. J Med Chem. 2021 1 28;64(3):1346-1361.
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Yadala V, Jafri H, Legenza MT, Tirona M. 2020. Breast cancer in a patient with Birt-Hogg-Dubé syndrome (BHDS) with dramatic response to neoadjuvant chemotherapy. BMJ Case Rep. 2020 2 7;13(2).
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Friedman JR, Richbart SD, Merritt JC, Perry HE, Brown KC, Akers AT, Nolan NA, Stevenson CD, Hurley JD, Miles SL, Tirona MT, Valentovic MA, Dasgupta P. 2019. Capsaicinoids enhance chemosensitivity to chemotherapeutic drugs. Adv. Cancer Res. 2019 7 28;144:263-298.
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Friedman JR, Richbart SD, Merritt JC, Brown KC, Denning KL, Tirona MT, Valentovic MA, Miles SL, Dasgupta P. 2019. Capsaicinoids: Multiple effects on angiogenesis, invasion and metastasis in human cancers. Biomed. Pharmacother. 2019 8 13;118:109317.
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Singh R, Ansinelli H, Katz H, Jafri H, Gress T, Tirona M. 2018. Factors Associated with Functional Decline in Elderly Female Breast Cancer Patients in Appalachia 2018 May 12; 10(5): e2612
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Numan Y, Amro A, Shah R, Hirzallah H, Sahay G, Kusmic D, Jawaid Y, Thompson EA, Tirona M. 2018. A longitudinal monitoing of left ventricular ejection fraction (LVEF) during reduced dosing anthracycline based chemotherapy in patients with breast cancer 36(15_Suppl);e12666-e12666

Katz H, Jafri H, Saad R, Limjoco T, Tirona MT. 2018. Colonic Obstruction from an Unusual Cause: A Rare Case of Metastatic Invasive Ductal Carcinoma to the Colon. Cureus. 2018 7 17;10(5):e2588.
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Singh R, Heisey H, Elsayed AG, Tirona MT. 2017. Adequate Neutrophil Responses and Non-Inferior Clinical Outcomes Can Be Achieved by a Two-Day Course of Low-Dose Filgrastim: A Retrospective Single Institution Experience 9(12): e1968. doi:10.7759/cureus.1968
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Elsayed AG, Srivastava R, Pacioles T, Limjoco T, Tirona MT. 2017. Ischemic Colitis Associated with Paclitaxel and Carboplatin Combination. Case Rep Oncol. 2017 9 8;10(2):689-693.
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Srikanthan K, Klug R, Tirona M, Thompson E, Visweshwar H, Puri N, Shapiro J, Sodhi K. 2017. Creating a Biomarker Panel for Early Detection of Chemotherapy Related Cardiac Dysfunction in Breast Cancer Patients. J Clin Exp Cardiolog. 2017 6 24;8(3).
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Raufi A, Tirona MT. 2017. Prospect of the use of checkpoint inhibitors in hepatocellular cancer treatments. Cancer Manag Res. 2017 2 23;9:19-27.
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Raufi A, Alsharedi M, Khelfa Y, Tirona M. 2017. Bilateral Triple-Negative Invasive Breast Cancer with a BRCA2 Mutation, and Glioblastoma: A Case Report and Literature Review. J Breast Cancer. 2017 4 7;20(1):108-111.
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Mozayen M, Alsharedi M, Mehmi I, Gress T, Tirona MT.. 2016. Delaying Chemotherapy In The Treatment Of Stage IV Non-Small Cell Lung Cancer Does Not Adversely Affect Survival Outcome 2016 Jan/Feb;112(1):34-7

Alsharedi M, Gress T, Dotson J, Elmsherghi N, Tirona MT. 2016. Comparison of toxicity profile and tolerability between two standard of care paclitaxel-based adjuvant chemotherapy regimens in breast cancer. Med. Oncol. 2016 Mar;33(3):27.
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Matt L, Mozayen M, Gress TW, Tirona MT. 2015. The Tri-State Experience. Outcome Analysis of Patients with Triple Negative Breast Cancer Treated at Marshall University. W V Med J. 2015 09;111(5):30-4.
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Tria Tirona M. 2013. Breast cancer screening update. Am Fam Physician. 2013 Feb 15;87(4):274-8.
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Tria Tirona M, Sehgal R, Ballester O. 2010. Prevention of Breast Cancer (Part I): Epidemiology, Risk Factors, and Risk Assessment Tools Cancer Invest. 2010;Aug; 28:743-750
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Tria Tirona, M, Sehgal R, Ballester O. 2010. Prevention of Breast Cancer (Part II): Risk Reduction Strategies Cancer Invest. 2010 Dec;28(10):1070-7
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Abraham J, Flanagan M, Hazard H, Jubelirer S, Tirona MT, Vona-Davis L. 2009. Triple-negative breast cancer in West Virginia. W V Med J. 2009 Oct;105 Spec No:54-9.
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Abraham J, Keresztury J, Azar J, Monga M, Bowers T, Jones MP, Tirona MT, Pollock J, Coonley C, Jubelirer S, Frame J, Fogg P, Getto M, Filburn S, Naim J, Lucas D, Petros W, Hall S, Remick SC. 2009. Building a statewide clinical trials network for cancer care in West Virginia. W V Med J. 2009 Oct;105 Spec No:6-11.
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